氟康唑类似物的研究进展

氟康唑是第三代三唑类抗真菌药物,具有水溶性好、广谱和低毒等优点,是临床上治疗真菌感染的首选药物。随着氟康唑耐药菌株的不断出现,研制新型氟康唑类似物成为重要的科研课题。通过对氟康唑结构的修饰,获得新型氟康唑类似物,为进一步的新药合成研究提供线索。...

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Bibliographic Details
Published in药学实践杂志 Vol. 34; no. 2; pp. 110 - 113
Main Author 许克寒 黄蕾 吴俊琪 戚麟 金永生 俞世冲
Format Journal Article
LanguageChinese
Published 第二军医大学药学院有机化学教研室,上海,200433 2016
Subjects
合成
抗真菌药
氟康唑
结构修饰
synthesis
合成
fluconazole
antifungal agents
结构修饰
氟康唑
抗真菌药
structural modification
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ISSN1006-0111
DOI10.3969/j.issn.1006-0111.2016.02.004

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Summary:氟康唑是第三代三唑类抗真菌药物,具有水溶性好、广谱和低毒等优点,是临床上治疗真菌感染的首选药物。随着氟康唑耐药菌株的不断出现,研制新型氟康唑类似物成为重要的科研课题。通过对氟康唑结构的修饰,获得新型氟康唑类似物,为进一步的新药合成研究提供线索。
Bibliography:31-1685/R
fluconazole; antifungal agents; structural modification; synthesis
XU Kehan;HUANG Lei;WU Junqi;QI Lin;JIN Yongsheng;YU Shichong;Department of Organic Chemistry,School of Pharmacy,Second Military Medical University; Shanghai 200433, China
Fluconazole,the third generation of triazole-antifungal drug,becomes the first choice in the treatment of fungal infection due to its broad antifungal spectrum,good water solubility and low toxicity.With an increasingly drug-resistant strain,developing new fluconazole derivatives is becoming an attractive topic.This review mainly indicates that people can get new fluconazole derivatives used by clinic through structural modification of fluconazole,which will give clues for advanced research.
ISSN:1006-0111
DOI:10.3969/j.issn.1006-0111.2016.02.004