原发性胆汗性肝硬化中B细胞免疫的研究进展
原发性胆汁性肝硬化（PBC）以肝内小胆管的损伤为特征，但其损伤机制尤其是B细胞免疫在其中发挥的作用尚不明确。从B细胞和浆细胞在PBC肝组织中的分布、B细胞清除、PBC血清中异常增高的IgM产生机制及其组织器官来源、线粒体抗体的产生机制以及在胆管损伤中的可能作用、PBC中特征性的自身抗体等方面，回顾了B细胞免疫在PBC发病机制中的可能作用。通过以上分析，认为B细胞免疫的确在PBC的发病机制中发挥了重要作用，但仍有很多关键的问题尚未得到阐明。...
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| Published in | 临床肝胆病杂志 Vol. 30; no. 5; pp. 400 - 404 |
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| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
首都医科大学附属复兴医院 检验科,北京,100038%首都医科大学附属北京佑安医院感染与免疫研究中心,北京,100069%首都医科大学附属北京佑安医院病理科,北京,100069
2014
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1001-5256 |
| DOI | 10.3969/j.issn.1001-5256.2014.05.004 |
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| Summary: | 原发性胆汁性肝硬化（PBC）以肝内小胆管的损伤为特征，但其损伤机制尤其是B细胞免疫在其中发挥的作用尚不明确。从B细胞和浆细胞在PBC肝组织中的分布、B细胞清除、PBC血清中异常增高的IgM产生机制及其组织器官来源、线粒体抗体的产生机制以及在胆管损伤中的可能作用、PBC中特征性的自身抗体等方面，回顾了B细胞免疫在PBC发病机制中的可能作用。通过以上分析，认为B细胞免疫的确在PBC的发病机制中发挥了重要作用，但仍有很多关键的问题尚未得到阐明。 |
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| Bibliography: | liver cirrhosis,biliary;immunity,humoral;B lymphocytes;review TAN Yanguo, YAN Huiping, GAO Zuhua. （ Department of Clinical laboratory, Fuxing Hospital, capital Medical University, Beijing 100038, China ） Primary biliary cirrhosis （PBC）is characterized by injury of small intrahepatic bile ducts,but its mechanism,especially the role of B cell immunity in this disease,remains unclear.The possible role of B cell immunity in the pathogenesis of PBC is reviewed from the following aspects：distribution of B cells and plasma cells in the liver tissues of PBC patients,clearance of B cells,mechanism of abnormal increase in serum IgM and its sources among PBC patients,mechanism of production of antimitochondrial antibodies and their possible functions in bile duct injury,and typical autoantibodies in PBC.B cell immunity is considered to play a significant role in the pathogenesis of PBC,but there are still many key problems to be clarified. 22-1108/R |
| ISSN: | 1001-5256 |
| DOI: | 10.3969/j.issn.1001-5256.2014.05.004 |