用紫外导数分光光度法测定复方替米沙坦氨氯地平片的含量
目的 测定复方片中替米沙坦和氨氯地平的含量。方法 采用紫外导数分光光度法,替米沙坦测定波长为236nm,氨氯地平测定波长为390nm。结果 替米沙坦浓度在(4~20)×10-3 mg/ml范围内与一阶导数值有良好的线性关系,其标准曲线方程为Y=0.004 3X-0.000 5,R2=0.999 3;氨氯地平浓度在(10~90)×10-3 mg/ml范围内与一阶导数值有良好的线性关系,其标准曲线方程为Y=0.000 3X+0.000 2,R2=0.999 5。结论 该方法具有较好的灵敏度、准确度和精密度;样品检测结果与HPLC法基本一致;是测定复方替米沙坦氨氯地平片含量的一种较好的分析方法。...
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Published in | 药学实践杂志 Vol. 35; no. 2; pp. 150 - 153 |
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Main Author | |
Format | Journal Article |
Language | Chinese |
Published |
湖北工业大学生物工程与食品学院 ,湖北武汉,430068
2017
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Subjects | |
Online Access | Get full text |
ISSN | 1006-0111 |
DOI | 10.3969/j.issn.1006-0111.2017.02.013 |
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Abstract | 目的 测定复方片中替米沙坦和氨氯地平的含量。方法 采用紫外导数分光光度法,替米沙坦测定波长为236nm,氨氯地平测定波长为390nm。结果 替米沙坦浓度在(4~20)×10-3 mg/ml范围内与一阶导数值有良好的线性关系,其标准曲线方程为Y=0.004 3X-0.000 5,R2=0.999 3;氨氯地平浓度在(10~90)×10-3 mg/ml范围内与一阶导数值有良好的线性关系,其标准曲线方程为Y=0.000 3X+0.000 2,R2=0.999 5。结论 该方法具有较好的灵敏度、准确度和精密度;样品检测结果与HPLC法基本一致;是测定复方替米沙坦氨氯地平片含量的一种较好的分析方法。 |
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AbstractList | 目的 测定复方片中替米沙坦和氨氯地平的含量。方法 采用紫外导数分光光度法,替米沙坦测定波长为236nm,氨氯地平测定波长为390nm。结果 替米沙坦浓度在(4~20)×10-3 mg/ml范围内与一阶导数值有良好的线性关系,其标准曲线方程为Y=0.004 3X-0.000 5,R2=0.999 3;氨氯地平浓度在(10~90)×10-3 mg/ml范围内与一阶导数值有良好的线性关系,其标准曲线方程为Y=0.000 3X+0.000 2,R2=0.999 5。结论 该方法具有较好的灵敏度、准确度和精密度;样品检测结果与HPLC法基本一致;是测定复方替米沙坦氨氯地平片含量的一种较好的分析方法。 O657; 目的 测定复方片中替米沙坦和氨氯地平的含量.方法 采用紫外导数分光光度法,替米沙坦测定波长为236 nm,氨氯地平测定波长为390 nm.结果 替米沙坦浓度在(4~20)×10-3 mg/ml范围内与一阶导数值有良好的线性关系,其标准曲线方程为Y=0.0043 X-0.0005,R2=0.9993;氨氯地平浓度在(10~90)×10-3 m g/m l范围内与一阶导数值有良好的线性关系,其标准曲线方程为Y=0.0003 X+0.0002,R2=0.9995.结论 该方法 具有较好的灵敏度、准确度和精密度;样品检测结果 与HPLC法基本一致;是测定复方替米沙坦氨氯地平片含量的一种较好的分析方法 . |
Abstract_FL | Objective To determine telmisartan and amlodipine assay in the compound tablet .Methods First derivative UV spectrophotometry was used at wavelength 236 nm for telmisartan and 390 nm for amlodipine .Results Telmisartan con-tent has a good linear relationship in the concentration range of (4~20) × 10-3 mg/ml .The standard curve equation is Y =0 .0043 X-0 .0005 and correlation coefficient R2 =0 .9993 .Amlodipine content has a good linear relationship in the concen-tration range of (10~90) × 10-3 mg/ml .The standard curve equation is Y =0 .0003 X+0 .0002 and correlation coefficient R2 =0 .9995 .Conclusion The assay results from this method are consistent with the results from HPLC .This procedure pro-vides a specific ,accurate and precise method to assay the amlodipine and telmisartan in compound tablet . |
Author | 苏江涛 胡常杰 张汉桥 张梦林 谢卫红 糜志远 |
AuthorAffiliation | 湖北工业大学生物工程与食品学院,湖北武汉430068 |
AuthorAffiliation_xml | – name: 湖北工业大学生物工程与食品学院 ,湖北武汉,430068 |
Author_FL | XIE Weihong MI Zhiyuan HU Changjie ZHANG Menglin SU Jiangtao ZHANG Hanqiao |
Author_FL_xml | – sequence: 1 fullname: SU Jiangtao – sequence: 2 fullname: HU Changjie – sequence: 3 fullname: ZHANG Hanqiao – sequence: 4 fullname: ZHANG Menglin – sequence: 5 fullname: XIE Weihong – sequence: 6 fullname: MI Zhiyuan |
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ClassificationCodes | O657 |
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DocumentTitleAlternate | Determination of amlodipine and telmisartan in the compound tablet by first derivative UV spectrophotometry |
DocumentTitle_FL | Determination of amlodipine and telmisartan in the compound tablet by first de-rivative UV spectrophotometry |
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Keywords | 含量测定 氨氯地平 替米沙坦 first derivative UV spectrophotometry telmisartan assay amlodipine 紫外导数分光光度法 |
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Notes | 31-1685/R Objective To determine telmisartan and amlodipine assay in the compound tablet. Methods First derivative UV spectrophotometry was used at wavelength 236 nm for telmisartan and 390 nm for amlodipine. Results Telmisartan content has a good linear relationship in the concentration range of (4~ 20) × 10 -3 mg/ml. The standard curve equation is Y= 0. 004 3 X-0. 000 5 and correlation coefficlent R2=0. 999 3. Amlodipine content has a good linear relationship in the concentration range of (10-90) × 10-3 mg/ml. The standard curve equation is Y= 0. 000 3 X+0. 000 2 and correlation coefficient R2 =0. 999 5. Conclusion The assay results from this method are consistent with the results from HPLC. This procedure provides a specific, accurate and precise method to assay the amlodipine and telmisartan in compound tablet. SU Jiangtao,HU Changjie, ZHANG Hanqiao, ZHANG Menglin, XIE Weihong, MI Zhiyuan (Biology and Food Engineering College, Hubei University of Technology, Wuhan 430068,China) first derivative UV spectropho |
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PublicationTitle | 药学实践杂志 |
PublicationTitleAlternate | The Journal of Pharmaceutical Practice |
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PublicationYear | 2017 |
Publisher | 湖北工业大学生物工程与食品学院 ,湖北武汉,430068 |
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Snippet | 目的 测定复方片中替米沙坦和氨氯地平的含量。方法 采用紫外导数分光光度法,替米沙坦测定波长为236nm,氨氯地平测定波长为390nm。结果 替米沙坦浓度在(4~20)×10-3 mg/ml范... O657; 目的 测定复方片中替米沙坦和氨氯地平的含量.方法 采用紫外导数分光光度法,替米沙坦测定波长为236 nm,氨氯地平测定波长为390 nm.结果 替米沙坦浓度在(4~20)×10-3... |
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SubjectTerms | 含量测定 替米沙坦 氨氯地平 紫外导数分光光度法 |
Title | 用紫外导数分光光度法测定复方替米沙坦氨氯地平片的含量 |
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