用紫外导数分光光度法测定复方替米沙坦氨氯地平片的含量

目的 测定复方片中替米沙坦和氨氯地平的含量。方法 采用紫外导数分光光度法,替米沙坦测定波长为236nm,氨氯地平测定波长为390nm。结果 替米沙坦浓度在（4～20）×10-3 mg/ml范围内与一阶导数值有良好的线性关系,其标准曲线方程为Y=0.004 3X-0.000 5,R2=0.999 3;氨氯地平浓度在（10～90）×10-3 mg/ml范围内与一阶导数值有良好的线性关系,其标准曲线方程为Y=0.000 3X＋0.000 2,R2=0.999 5。结论 该方法具有较好的灵敏度、准确度和精密度;样品检测结果与HPLC法基本一致;是测定复方替米沙坦氨氯地平片含量的一种较好的分析方法。...

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Bibliographic Details
Published in药学实践杂志 Vol. 35; no. 2; pp. 150 - 153
Main Author 苏江涛 胡常杰 张汉桥 张梦林 谢卫红 糜志远
Format Journal Article
LanguageChinese
Published 湖北工业大学生物工程与食品学院 ,湖北武汉,430068 2017
Subjects
含量测定
替米沙坦
氨氯地平
紫外导数分光光度法
含量测定
氨氯地平
替米沙坦
first derivative UV spectrophotometry
telmisartan
assay
amlodipine
紫外导数分光光度法
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ISSN1006-0111
DOI10.3969/j.issn.1006-0111.2017.02.013

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Summary:目的 测定复方片中替米沙坦和氨氯地平的含量。方法 采用紫外导数分光光度法,替米沙坦测定波长为236nm,氨氯地平测定波长为390nm。结果 替米沙坦浓度在（4～20）×10-3 mg/ml范围内与一阶导数值有良好的线性关系,其标准曲线方程为Y=0.004 3X-0.000 5,R2=0.999 3;氨氯地平浓度在（10～90）×10-3 mg/ml范围内与一阶导数值有良好的线性关系,其标准曲线方程为Y=0.000 3X＋0.000 2,R2=0.999 5。结论 该方法具有较好的灵敏度、准确度和精密度;样品检测结果与HPLC法基本一致;是测定复方替米沙坦氨氯地平片含量的一种较好的分析方法。
Bibliography:31-1685/R
Objective To determine telmisartan and amlodipine assay in the compound tablet. Methods First derivative UV spectrophotometry was used at wavelength 236 nm for telmisartan and 390 nm for amlodipine. Results Telmisartan content has a good linear relationship in the concentration range of （4～ 20） × 10 -3 mg/ml. The standard curve equation is Y= 0. 004 3 X-0. 000 5 and correlation coefficlent R2=0. 999 3. Amlodipine content has a good linear relationship in the concentration range of （10-90） × 10-3 mg/ml. The standard curve equation is Y= 0. 000 3 X＋0. 000 2 and correlation coefficient R2 =0. 999 5. Conclusion The assay results from this method are consistent with the results from HPLC. This procedure provides a specific, accurate and precise method to assay the amlodipine and telmisartan in compound tablet.
SU Jiangtao,HU Changjie, ZHANG Hanqiao, ZHANG Menglin, XIE Weihong, MI Zhiyuan （Biology and Food Engineering College, Hubei University of Technology, Wuhan 430068,China）
first derivative UV spectropho
ISSN:1006-0111
DOI:10.3969/j.issn.1006-0111.2017.02.013