抗骨质疏松治疗药物研究的新进展
骨质疏松是一种常见的全身性骨代谢疾病,主要表现为骨密度与骨量的下降,从而导致继发性骨折.目前,随 着其发病率不断增高,骨质疏松已经成为一个世界范围的健康问题和当前医学的研究热点.骨吸收抑制剂主要作用于破骨 细胞, 通过抑制破骨细胞分化成熟, 减少骨吸收; 骨形成促进剂主要作用于成骨细胞, 激活其骨形成功能, 并且有重建骨组织 的效应;骨矿化物是防治骨质疏松的基础药物, 包括钙剂和维生素D ;解偶联剂种类较为单一, 代表药物为雷尼酸锶.主要对 以上四大类抗骨质疏松药物的研究进展进行介绍....
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| Published in | 药学实践杂志 Vol. 35; no. 6; pp. 490 - 494 |
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| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
海军青岛第一疗养院药剂科,山东 青岛,266071%第二军医大学药学院有机化学教研室,上海,200433
2017
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1006-0111 |
| DOI | 10.3969/j.issn.1006-0111.2017.06.003 |
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| Summary: | 骨质疏松是一种常见的全身性骨代谢疾病,主要表现为骨密度与骨量的下降,从而导致继发性骨折.目前,随 着其发病率不断增高,骨质疏松已经成为一个世界范围的健康问题和当前医学的研究热点.骨吸收抑制剂主要作用于破骨 细胞, 通过抑制破骨细胞分化成熟, 减少骨吸收; 骨形成促进剂主要作用于成骨细胞, 激活其骨形成功能, 并且有重建骨组织 的效应;骨矿化物是防治骨质疏松的基础药物, 包括钙剂和维生素D ;解偶联剂种类较为单一, 代表药物为雷尼酸锶.主要对 以上四大类抗骨质疏松药物的研究进展进行介绍. |
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| Bibliography: | 31-1685/R osteoporosis ; drugs ; therapy ;anti-resorptive drugs ; bone-anabolic drugs ; bone mineralization-acceleration drugs Osteoporosis （OP） is a systemic bone metabolism disease characterized by a systemic impairment of bone mass, strength,and microarchitecture,which will be result in increasing the propensity of fragility fractures . In recent years, OP becomes a worldwide health problem and a hotspot in medical research due to its increasing incidence . Anti-resorptive drugs inhibit osteoclast differentiation and maturation in order to reduce bone resorption, Bone-anabolic drugs promote the bone for-mation function of osteoblast and reconstruct bone tissue , Bone mineralization-acceleration drugs are the basic material for pre-vention and treatment of osteoporosis , including calcium and vitamin D , Strontium ranelate is the representative drug of un - coupling agents . In this paper,the current progress of osteoporosis treatments were reviewed including these proposed drugs . JIA Wenbin1,LIU Chao2 , ZOU |
| ISSN: | 1006-0111 |
| DOI: | 10.3969/j.issn.1006-0111.2017.06.003 |