肿瘤相关糖抗原GM3及其衍生物合成方法研究进展

GM3及其衍生物合成中的糖苷化反应条件苛刻，端基碳的立体构型较难控制，能否高效地得到α糖苷键是评价反应优劣的重要标志之一。笔者综述了近年来GM3及其衍生物的合成方法，涉及糖供体化合物的选择、糖受体的确定、立体选择性的控制及新糖苷化反应催化剂的发展。...

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Bibliographic Details
Published in药学实践杂志 Vol. 34; no. 1; pp. 5 - 7
Main Author 白国静 边晓杰 姚阔 吴俊琪 俞世冲 孟庆国 吴秋业
Format Journal Article
LanguageChinese
Published 烟台大学药学院，山东 烟台 264005 2016
第二军医大学药学院，上海200433%第二军医大学药学院,上海,200433%烟台大学药学院,山东 烟台,264005
Subjects
GM3及其衍生物
合成
立体选择性
糖供体
糖受体
糖苷化反应
糖供体
synthesis
合成
GM3及其衍生物
stereoselectivity
GM3 and derivatives
glycosylacceptor
立体选择性
糖苷化反应
glycosylation
glycosyl donor
糖受体
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ISSN1006-0111
DOI10.3969/j.issn.1006-0111.2016.01.002

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Summary:GM3及其衍生物合成中的糖苷化反应条件苛刻，端基碳的立体构型较难控制，能否高效地得到α糖苷键是评价反应优劣的重要标志之一。笔者综述了近年来GM3及其衍生物的合成方法，涉及糖供体化合物的选择、糖受体的确定、立体选择性的控制及新糖苷化反应催化剂的发展。
Bibliography:31-1685/R
GM3 and derivatives ; synthesis, glycosyl donor ; glycosylacceptor ; glycosylation; stereoselectivity
BAI Guojing ,BIAN Xiaojie , YAO Kuo , WU Junqi , YU Shichong , MENG Qingguo , WU Qiuye （1. College of Phar- macy, Yantai University, Yantai 264005, China; 2. School of Pharmacy, Second Military Medical University, Shanghai 200433, China）
Glycosylation is the key step of the synthesis of GM3, its reaction conditions are very harsh, the stereoselec- tivities are usually poor, and the configuration of anomeric carbon is difficult to control. Whether α glycosidic bond can be con- structed efficiently in sialylation reactions is an important criteria used to evaluate the reaction quality. Studies of GM3 and de- rivatives methods generally relates to following areas： the choice of the donor compounds and receptor compounds, the control of stereoselectivity, and the development of some new glycosidic reaction catalyst. In recent years, important progress has been made in this research area. Now, we predominat
ISSN:1006-0111
DOI:10.3969/j.issn.1006-0111.2016.01.002