非酒精性脂肪肝发病机制——“二次打击”学说研究进展

非酒精性脂肪肝（NAFLD）是肝脏系统中一类最为普遍的肝脏疾病。近年来,随着生活水平的提高,其发病率也逐年上升。由于NAFLD发病的隐匿性,其具体的发病机制目前仍不清楚,＂二次打击＂学说在其中的重要地位已得到一致认可。现就NAFLD发病机制与＂二次打击＂相关的细胞因子、代谢以及免疫方面等因素作一综述。...

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Published in临床肝胆病杂志 Vol. 28; no. 7; pp. 551 - 555
Main Author 董姝 刘平 孙明瑜
Format Journal Article
LanguageChinese
Published 上海高校中医内科学E-研究院,上海201203%上海中医药大学附属曙光医院上海中医药大学肝病研究所肝肾疾病病证教育部重点实验室,上海201203 2012
上海高校中医内科学E-研究院,上海201203
上海中医药大学附属曙光医院上海中医药大学肝病研究所肝肾疾病病证教育部重点实验室,上海201203
上海中医药大学,上海201203%上海中医药大学附属曙光医院上海中医药大学肝病研究所肝肾疾病病证教育部重点实验室,上海201203
上海中医药大学,上海201203
Subjects
二次打击
脂肪肝
脂肪肝
二次打击
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ISSN1001-5256

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Summary:非酒精性脂肪肝（NAFLD）是肝脏系统中一类最为普遍的肝脏疾病。近年来,随着生活水平的提高,其发病率也逐年上升。由于NAFLD发病的隐匿性,其具体的发病机制目前仍不清楚,＂二次打击＂学说在其中的重要地位已得到一致认可。现就NAFLD发病机制与＂二次打击＂相关的细胞因子、代谢以及免疫方面等因素作一综述。
Bibliography:fatty liver; two-hit
The manifestation of non-alcoholic fatty liver disease（NAFLD） ranges from simple steatosis to non-alcoholic steatohepatitis.The ＂two-hit＂ hypothesis of NAFLD is widely accepted as an accurate description of the underlying pathogenic mechanism.The first hit is an increased fat flux to the liver,which predisposes a patient to the second hit,in which increased mitochondrial free fatty acid oxidation promotes oxidative stress,lipoperoxidation,and increased reactive oxygen species.In this review,we discuss the roles of immune-and inflammation-related factors,such as cytokines,and metabolic factors in the ＂two-hit＂ process of NAFLD.
DONG Shu,LIU Ping,SUN Ming-yu.（Key Laboratory of Liver and Kidney Diseases,Institute of Liver Diseases,Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China）
22-1108/R
ISSN:1001-5256