The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation provides a better definition of cardiovascular burden associated with CKD than the Modification of Diet in Renal Disease (MDRD) Study formula in subjects with type 2 diabetes

The chronic kidney disease (CKD)-Epidemiology Collaboration (EPI) equation was shown to be more accurate than the Modification of Diet in Renal Disease (MDRD) Study formula for estimating glomerular filtration rate (GFR) in the general population. This study was aimed at assessing cardiovascular dis...

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Published inAtherosclerosis Vol. 218; no. 1; pp. 194 - 199
Main Authors Pugliese, Giuseppe, Solini, Anna, Bonora, Enzo, Orsi, Emanuela, Zerbini, Gianpaolo, Giorgino, Francesco, Cavalot, Franco, Pontiroli, Antonio E., Baroni, Marco G., Morano, Susanna, Nicolucci, Antonio, Penno, Giuseppe
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier Ireland Ltd 01.09.2011
Elsevier
Subjects
GFR
NKF
AER
BP
CVD
GFR
CKD
CHD
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ISSN0021-9150
1879-1484
1879-1484
DOI10.1016/j.atherosclerosis.2011.04.035

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Summary:The chronic kidney disease (CKD)-Epidemiology Collaboration (EPI) equation was shown to be more accurate than the Modification of Diet in Renal Disease (MDRD) Study formula for estimating glomerular filtration rate (GFR) in the general population. This study was aimed at assessing cardiovascular disease (CVD) burden associated with CKD in type 2 diabetes, using these two GFR estimating formulas for CKD definition. This cohort study examined 15,773 Caucasian patients with type 2 diabetes participating in the Renal Insufficiency And Cardiovascular Events Italian Multicenter Study (NCT00715481) and attending the baseline visit in 19 diabetes clinics in years 2007–2008. Serum creatinine was assessed by the modified Jaffe method. Albuminuria was measured by immunonephelometry or immunoturbidimetry. CKD was defined as an estimated GFR (eGFR) <60mL/min/1.73m2 and/or micro/macroalbuminuria. Prevalence of impaired eGFR and CKD decreased from 18.7% to 17.2% (P=0.0012) and from 37.5% to 36.3% (P=0.077), respectively, with the CKD-EPI, as compared with the MDRD Study equation. Subjects with impaired eGFR or CKD with the MDRD Study equation only showed lower CVD prevalence rates and coronary heart disease risk scores, mainly driven by prevailing female sex, younger age and shorter diabetes duration, as compared with those with both formulas, whereas opposite figures were observed in patients falling into these categories with the CKD-EPI equation only. Estimating GFR in patients with type 2 diabetes using the CKD-EPI equation provides a better definition of CVD burden associated with CKD not only in individuals reclassified upward, but also in those reclassified downward.
Bibliography:http://dx.doi.org/10.1016/j.atherosclerosis.2011.04.035
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ISSN:0021-9150
1879-1484
1879-1484
DOI:10.1016/j.atherosclerosis.2011.04.035