Human Bocavirus: A Cause of Severe Asthma Exacerbation in Children

• Published in: The Journal of pediatrics Vol. 155; no. 2; pp. 286 - 288
• Main Authors: Vallet, Christelle, Pons-Catalano, Charlotte, Mandelcwajg, Alexis, Wang, Andrew, Raymond, Josette, Lebon, Pierre, Gendrel, Dominique
• Format: Journal Article
• Language: English
• Published: Maryland Heights, MO Mosby, Inc 01.08.2009; Elsevier
• Subjects: Adolescent; Age; Asthma - virology; Biological and medical sciences; Bocavirus - genetics; Bocavirus - isolation & purification; Child; Child, Preschool; DNA, Viral - isolation & purification; Female; General aspects; Hospitalization; Humans; Male; Medical sciences; Nasopharynx - virology; Parvoviridae Infections - epidemiology; Pediatrics; Polymerase Chain Reaction; Prospective Studies; Seasons; Severity of Illness Index; HboV; MP; RSV; HMPV; NPA; PCR; PICU; Mycoplasma pneumoniae; Human bocavirus; Polymerase chain reaction; Nasopharyngeal aspirate; Respiratory syncytial virus; Pediatric intensive care unit; Human metapneumovirus; Human; Exacerbation; Pediatrics; Cause; Severe asthma; Aggravation; Child
• ISSN: 0022-3476; 1097-6833; 1097-6833
• DOI: 10.1016/j.jpeds.2009.01.069

Real-time polymerase chain reaction for human bocavirus (HBoV) was performed in nasopharyngeal aspirate specimens from 166 children over 2 years of age hospitalized for severe asthma exacerbation. Whereas HBoV was detected in 21 of these children (13%), it was found in only 1 of 50 ambulatory children with stable asthma (2%), suggesting a major role of HBoV in acute exacerbations in asthmatic children.