Upregulation of HAb18G/CD147 in activated human umbilical vein endothelial cells enhances the angiogenesis

• Published in: Cancer Letters Vol. 278; no. 1; pp. 113 - 121
• Main Authors: Chen, Yanke, Zhang, Hongxin, Gou, Xingchun, Horikawa, Yohei, Xing, Jinliang, Chen, Zhinan
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 08.06.2009; Elsevier BV; Elsevier Limited
• Subjects: Angiogenesis; Antigens, CD; Antigens, CD - genetics; Apoptosis; Basigin; Basigin - genetics; Cell growth; Cell Movement; Endothelium, Vascular; Endothelium, Vascular - cytology; Endothelium, Vascular - physiology; Flow Cytometry; Genotype & phenotype; HAb18G/CD147; Hematology, Oncology and Palliative Medicine; Human umbilical vein endothelial cells; Humans; In Situ Nick-End Labeling; Neoplasms; Neoplasms - genetics; Neovascularization, Pathologic; Neovascularization, Pathologic - genetics; Neovascularization, Physiologic; Neovascularization, Physiologic - genetics; Proteins; RNA, Small Interfering; RNA, Small Interfering - genetics; Studies; Umbilical Veins; Umbilical Veins - cytology; Umbilical Veins - physiology; Up-Regulation; Vascular endothelial growth factor; Angiogenesis; HAb18G/CD147; Human umbilical vein endothelial cells
• ISSN: 0304-3835; 1872-7980; 1872-7980
• DOI: 10.1016/j.canlet.2009.01.004

Previous studies demonstrated that CD147 molecule, highly expressed on the surface of various malignant tumor cells, significantly correlated with the malignancy of these cancers; however, the role of HAb18G/CD147 in endothelial cells has yet to be established. In this study, we found that the expression of HAb18G/CD147 was significantly upregulated in activated HUVECs. The inhibition of HAb18G/CD147 expression by specific siRNA led to significantly decreased angiogenesis in vitro. Our data indicate that HAb18G/CD147 may regulate angiogenesis via several mechanisms including proliferation, survival, migration, MMPs secretion, and PI3K/Akt activation. Our findings for the first time suggest that upregulation of HAb18G/CD147 in activated HUVECs might play an important role in angiogenesis.