聚醚醚酮种植材料TiO2颗粒喷砂处理的生物活性研究

目的探讨Ti O2颗粒喷砂处理聚醚醚酮（PEEK）的最佳粒度范围。方法用5种粒度范围的Ti O2颗粒（A-E组）对PEEK进行喷砂处理,进行表面粗糙度检测,观察细胞黏附、细胞增殖、细胞形貌,并检测碱性磷酸酶（ALP）活性。结果 PEEK的表面粗糙度随着喷砂Ti O2颗粒的粒度增大而增加。同时发现了多个峰值的存在,细胞黏附实验OD值的峰值出现在C组（180-212μm Ti O2颗粒进行喷砂）,数值为0.566 2。经过14 d培养,成骨细胞ALP活性峰值出现在D组（〉212-355μm Ti O2颗粒进行喷砂）。结论 PEEK表面喷砂的最佳Ti O2颗粒粒度范围为180-355μm,可为今后P...

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Bibliographic Details
Published in现代医药卫生 Vol. 31; no. 12; pp. 1761 - 1763
Main Author 吴晓绵 胡小蕾 邓锋
Format Journal Article
LanguageChinese
Published 重庆医科大学口腔医学院/口腔疾病与生物医学重庆市重点实验室/重庆市高校市级口腔生物医学工程重点实验室，重庆401147 2015
重庆医科大学附属口腔医院正畸科，重庆400015%重庆医科大学检验医学院临床检验诊断学重点实验室,重庆,400016
Subjects
二氧化钛
生物力学
生物相容性材料
碱性磷酸酶
聚醚醚酮
骨和骨组织
生物力学
Biomechanics
骨和骨组织
Alkaline phosphatase
Bone and bones
二氧化钛
Biocompatible materials
生物相容性材料
Polyetheretherketone
聚醚醚酮
碱性磷酸酶
TiO2
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ISSN1009-5519
DOI10.3969/j.issn.1009-5519.2015.12.001

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Summary:目的探讨Ti O2颗粒喷砂处理聚醚醚酮（PEEK）的最佳粒度范围。方法用5种粒度范围的Ti O2颗粒（A-E组）对PEEK进行喷砂处理,进行表面粗糙度检测,观察细胞黏附、细胞增殖、细胞形貌,并检测碱性磷酸酶（ALP）活性。结果 PEEK的表面粗糙度随着喷砂Ti O2颗粒的粒度增大而增加。同时发现了多个峰值的存在,细胞黏附实验OD值的峰值出现在C组（180-212μm Ti O2颗粒进行喷砂）,数值为0.566 2。经过14 d培养,成骨细胞ALP活性峰值出现在D组（〉212-355μm Ti O2颗粒进行喷砂）。结论 PEEK表面喷砂的最佳Ti O2颗粒粒度范围为180-355μm,可为今后PEEK表面改性研究提供重要参考。
Bibliography:Objective To find out the best granularity range of TiO2 particles blasting process on polyether-ether-ketone （PEEK）. Methods Five kinds of granule range of TiO2 particles（group A-E） were utilized for conducting the surface blasting pro-cess on PEEK. The surface roughness was tested,the cell attachment,cell proliferation and cell morphology were observed and alka-line phosphatase（ALP） activity was detected. Results The roughness of blasted PEEK surface was increased as the increase of TiO 2 particles granularity. At the same time several peak values were found. In the cell attachment test ,the peak OD value appeared in the group C（blasting by 180-212μm of TiO2 particles）,which was 0.566 2. After 14 d culture,the peak value of osteoblast ALP activi-ty appeared in the group D（blasting by〉212-355μm of TiO2 particles）. Conclusion The best granularity range of TiO2 particles for PEEK surface blasting is 180-355μm,which can provide an important reference for the future study of PEEK surface modifi-cation in the fut
ISSN:1009-5519
DOI:10.3969/j.issn.1009-5519.2015.12.001