TRAIL、MAP-2和Nestin在流产患者绒毛组织中的表达及意义
目的探讨肿瘤坏死因子相关凋亡诱导配体(TRAIL)、微管相关蛋白2(MAP-2)和巢蛋白(Nestin)与自然流产和人工流产绒毛发育的关系。方法选择2007年6月至2008年6月在浙江省绍兴市计划生育宣传技术指导站门诊接受自然流产的患者40例及同期进行人工流产的患者60例(作为对照)。应用免疫组化法检测第40~90天自然流产和人工流产患者胎盘绒毛和蜕膜组织中TRAIL、MAP-2和Nestin的表达,并分析其分布规律。结果妊娠第40~90天人工流产患者绒毛和蜕膜组织中少数细胞TRAIL呈阳性表达,自然流产患者绒毛和蜕膜组织中多数细胞TRAIL呈阳性表达;人工流产患者绒毛组织中MAP-2呈阴性表...
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          | Published in | 现代医药卫生 Vol. 31; no. 17; pp. 2569 - 2571 | 
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| Main Author | |
| Format | Journal Article | 
| Language | Chinese | 
| Published | 
            绍兴文理学院附属医院,浙江绍兴,312000%绍兴文理学院医学院,浙江绍兴,312000%绍兴市计划生育宣传技术指导站,浙江,312000
    
        2015
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| Subjects | |
| Online Access | Get full text | 
| ISSN | 1009-5519 | 
| DOI | 10.3969/j.issn.1009-5519.2015.17.001 | 
Cover
| Summary: | 目的探讨肿瘤坏死因子相关凋亡诱导配体(TRAIL)、微管相关蛋白2(MAP-2)和巢蛋白(Nestin)与自然流产和人工流产绒毛发育的关系。方法选择2007年6月至2008年6月在浙江省绍兴市计划生育宣传技术指导站门诊接受自然流产的患者40例及同期进行人工流产的患者60例(作为对照)。应用免疫组化法检测第40~90天自然流产和人工流产患者胎盘绒毛和蜕膜组织中TRAIL、MAP-2和Nestin的表达,并分析其分布规律。结果妊娠第40~90天人工流产患者绒毛和蜕膜组织中少数细胞TRAIL呈阳性表达,自然流产患者绒毛和蜕膜组织中多数细胞TRAIL呈阳性表达;人工流产患者绒毛组织中MAP-2呈阴性表达,自然流产患者绒毛组织中MAP-2呈广泛阳性表达;人工流产患者绒毛组织中位于绒毛腔、紧靠细胞滋养层血管内皮细胞Nestin呈阳性表达,自然流产患者绒毛腔内仅少量血管内皮细胞Nestin呈弱阳性表达。结论 TRAIL、MAP-2和Nestin的表达状况与绒毛组织细胞发育及妊娠关系密切。 | 
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| Bibliography: | Abortion,spontaneous; Chorion; Microtubule-associated proteins; TNF-related apoptosis-inducingligand; Immunohistochemistry Zhu Lvchong, Liu Xuehong, Zhang Yong , He Shuying (1. Affiliated Hospital of Shaoxing University, Shaoxing , Zhejiang 312000, China; 2. Medical College of Shaoxing University ,Shaoxing ,Zhejiang 312000,China;3. Shaoxing Municipal Guidance Station of Family Planning Publicity Technique, Zhejiang 312000, China) Objective To investigate the relationship between TNF-related apoptosis inducing ligand (TRAIL), microtubules related protein 2 (MAP-2) and Nestin with chorionic villus development in the spontaneous abortion and artificial abortion. Methods 40 cases of spontaneous abortion and contemporaneous 60 cases of artificial abortion as the controls in the outpatient department of the Shaoxing Municipal Guidance Station of Family Planning Publicity Technique were selected and detected the expressions of TRAIL, MAP-2 and Nestin in the decidual and cborionic villus tissues on pregnant 40-90 d by  | 
| ISSN: | 1009-5519 | 
| DOI: | 10.3969/j.issn.1009-5519.2015.17.001 |