A frequency peak at 3.1 kHz obtained from the spectral analysis of the cochlear implant electrocochleography noise

• Published in: PloS one Vol. 19; no. 3; p. e0299911
• Main Authors: Herrada, Javiera, Medel, Vicente, Dragicevic, Constantino, Maass, Juan C., Stott, Carlos E., Delano, Paul H.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 07.03.2024; Public Library of Science (PLoS)
• Subjects: Acoustic nerve; Acoustic Stimulation - methods; Adult; Aged; Analysis; Animals; Audiometry, Evoked Response - methods; Auditory perception; Biology and Life Sciences; Cochlear Implantation; Cochlear Implants; Cochlear Nerve - physiology; Computer and Information Sciences; Engineering and Technology; Female; Health aspects; Humans; Implants, Artificial; Medical examination; Medicine and Health Sciences; Middle Aged; Noise; Physical Sciences; Prosthesis; Social Sciences; Chile
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0299911

The functional evaluation of auditory-nerve activity in spontaneous conditions has remained elusive in humans. In animals, the frequency analysis of the round-window electrical noise recorded by means of electrocochleography yields a frequency peak at around 900 to 1000 Hz, which has been proposed to reflect auditory-nerve spontaneous activity. Here, we studied the spectral components of the electrical noise obtained from cochlear implant electrocochleography in humans. We recruited adult cochlear implant recipients from the Clinical Hospital of the Universidad de Chile, between the years 2021 and 2022. We used the AIM System from Advanced Bionics® to obtain single trial electrocochleography signals from the most apical electrode in cochlear implant users. We performed a protocol to study spontaneous activity and auditory responses to 0.5 and 2 kHz tones. Twenty subjects including 12 females, with a mean age of 57.9 ± 12.6 years (range between 36 and 78 years) were recruited. The electrical noise of the single trial cochlear implant electrocochleography signal yielded a reliable peak at 3.1 kHz in 55% of the cases (11 out of 20 subjects), while an oscillatory pattern that masked the spectrum was observed in seven cases. In the other two cases, the single-trial noise was not classifiable. Auditory stimulation at 0.5 kHz and 2.0 kHz did not change the amplitude of the 3.1 kHz frequency peak. We found two main types of noise patterns in the frequency analysis of the single-trial noise from cochlear implant electrocochleography, including a peak at 3.1 kHz that might reflect auditory-nerve spontaneous activity, while the oscillatory pattern probably corresponds to an artifact.