维生素D在慢性阻塞性肺疾病治疗中的应用价值meta分析

目的系统评价维生素D在慢性阻塞性肺疾病治疗中的应用价值,为临床治疗提供循证参考。方法输入关键词,利用计算机检索Medline、EMBase、Pub Med、Cochrane图书馆、中国知网、维普数据库、万方数据库,对纳入的随机对照试验（RCT）进行文献质量评价,采用Rev Man 5.2统计软件进行分析。结果纳入11项RCT,合计1 357例患者。meta分析结果显示,观察组的第一秒用力呼吸容积（FEV1）占预计值百分比（FEV1%）较对照组显著提高,FEV1%合并效应量均数差（MD）（95%CI）为9.78[7.30,12.26],经Z检验,差异有统计学意义（Z=7.73,P〈0.01）;观...

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Bibliographic Details
Published in现代医药卫生 Vol. 32; no. 8; pp. 1146 - 1149
Main Author 王东梅 周向东
Format Journal Article
LanguageChinese
Published 重庆医科大学附属第二医院呼吸内科,重庆,400010 2016
Subjects
Meta分析
痰
维生素D
肺疾病,慢性阻塞性
痰
维生素D
Meta分析
肺疾病,慢性阻塞性
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ISSN1009-5519
DOI10.3969/j.issn.1009-5519.2016.08.010

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Summary:目的系统评价维生素D在慢性阻塞性肺疾病治疗中的应用价值,为临床治疗提供循证参考。方法输入关键词,利用计算机检索Medline、EMBase、Pub Med、Cochrane图书馆、中国知网、维普数据库、万方数据库,对纳入的随机对照试验（RCT）进行文献质量评价,采用Rev Man 5.2统计软件进行分析。结果纳入11项RCT,合计1 357例患者。meta分析结果显示,观察组的第一秒用力呼吸容积（FEV1）占预计值百分比（FEV1%）较对照组显著提高,FEV1%合并效应量均数差（MD）（95%CI）为9.78[7.30,12.26],经Z检验,差异有统计学意义（Z=7.73,P〈0.01）;观察组的FEV1占用力肺活量（FVC）的百分比即FEV1/FVC较对照组也有所提高,FEV1/FVC合并效应量MD（95%CI）为0.09[1.63,18.55],经Z检验,差异有统计学意义（Z=2.34,P=0.02）;观察组慢性阻塞性肺病评估测试（CAT）评分较对照组显著降低,CAT评分合并效应量MD（95%CI）为-5.16[-5.81,-4.52],经Z检验,差异有统计学意义（Z=15.78,P〈0.01）;观察组较对照组痰量减少,痰量合并效应量MD（95%CI）为-6.60[-7.27,-5.93],经Z检验,差异有统计学意义（Z=19.39,P〈0.01）;观察组血清25（OH）D水平较对照组显著提高,其合并效应量MD（95%CI）为13.87[11.84,15.90],经Z检验,差异有统计学意义（Z=13.37,P〈0.01）。结论补充维生素D能更好地改善患者肺功能、健康状况,减少临床症状,提高血清25（OH）D水平。但受纳入研究质量和设计方法学的限制,该结论需大样本、高质量的RCT进一步验证。
Bibliography:Meta-analysis; Vitamin D; Pulmonary disease; chronic obstructive; Sputum
Objective To systematically assess the application value of vitamin D supplements in the treatment of chronic obstructive pulmonary disease（COPD） to provide evidence-based reference for clinical treatment. Methods The Medline,EM Base,Pub Med,Cochrane library,CNKI,VIP database and Wan Fang databases were retrieved by entering the key words. The included randomized controlled trails（ RCTs） were performed the literature quality assessment and analyzed by adopting the Rev Man 5.2 software. Results Eleven randomized controlled trials（RCTs） were included,including 1 357 patients. The meta analysis results demonstrated that FEV1% in the observation group was significantly increased compared with the control group,the merge effect size mean difference（MD） of FEV1%（95%CI）was 9.78[7.30,12.26] with statistical difference（Z=7.73,P〈0.01）;FEV1/FVC was also increased compared with the control group,the merge effect size MD（95%CI） was 0.09[1.63,18.55] wi
ISSN:1009-5519
DOI:10.3969/j.issn.1009-5519.2016.08.010