肺癌硬膜下脊髓外转移患者临床特征分析

背景与目的肺癌硬膜下脊髓外转移罕见,可导致严重的神经损害,本研究旨在阐明其临床特征。方法 2013年5月-2016年5月,北京协和医院8例确诊硬膜下脊髓外转移肺癌患者纳入该研究,系统回顾分析临床资料。结果 7例非小细胞肺癌及1例小细胞肺癌合并硬膜下脊髓外转移。马尾综合征是最常见的临床表现。行腰椎穿刺的5例（100%）患者脑脊液找到肿瘤细胞。脊髓增强核磁（magnetic resonance imaging,MRI）发现,3例软脊膜弥漫线样增强,4例硬膜下脊髓外多发结节,1例具有上述两种表现。4例接受靶向治疗和/或放疗患者神经系统症状改善或稳定。中位生存时间是5.8个月。结论硬膜下脊髓外转移需依...

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Bibliographic Details
Published in中国肺癌杂志 Vol. 19; no. 8; pp. 539 - 544
Main Author 徐燕 钟巍 赵静 陈闽江 李龙芸 王孟昭
Format Journal Article
LanguageChinese
Published 100730北京，中国医学科学院，北京协和医学院，北京协和医院呼吸内科 2016
Subjects
硬膜下脊髓外转移
肺肿瘤
脊髓
脑膜转移癌
Spinal cord
脑膜转移癌
脊髓
Leptomeningeal metastasis
Intradural extramedullary metastases
硬膜下脊髓外转移
肺肿瘤
Lung neoplasms
Online AccessGet full text
ISSN1009-3419
1999-6187
DOI10.3779/j.issn.1009-3419.2016.08.10

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Summary:背景与目的肺癌硬膜下脊髓外转移罕见,可导致严重的神经损害,本研究旨在阐明其临床特征。方法 2013年5月-2016年5月,北京协和医院8例确诊硬膜下脊髓外转移肺癌患者纳入该研究,系统回顾分析临床资料。结果 7例非小细胞肺癌及1例小细胞肺癌合并硬膜下脊髓外转移。马尾综合征是最常见的临床表现。行腰椎穿刺的5例（100%）患者脑脊液找到肿瘤细胞。脊髓增强核磁（magnetic resonance imaging,MRI）发现,3例软脊膜弥漫线样增强,4例硬膜下脊髓外多发结节,1例具有上述两种表现。4例接受靶向治疗和/或放疗患者神经系统症状改善或稳定。中位生存时间是5.8个月。结论硬膜下脊髓外转移需依靠神经系统症状及增强MRI影像学检查诊断。靶向治疗和/或放疗可能有效。
Bibliography:Yan XU,Wei ZHONG,Jing ZHAO,Minjiang CHEN,Longyun LI,Mengzhao WANG（Department of Respiratory Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China）
Lung neoplasms; Leptomeningeal metastasis; Spinal cord; Intradural extramedullary metastases
Background and objective Intradural extramedullary spinal cord metastases in lung cancer is rare, and it leads to severe neurological damage. The aim of this study is to identify the clinical features of intradural extramedullary spinal cord metastases in primary lung cancer patients. Methods The 8 cases of lung cancer with intradural extramedullary metastases, who were hospitalized in Peking Union Medical College Hospital（PUMCH） during May 2013 to May 2016, were enrolled in the retrospective study. Medical charts of the 8 patients were reviewed systematically. Results Intradural extramedullary spinal cord metastases was diagnosed in 7 cases with non-small cell lung cancer（NSCLC） and 1 case w
ISSN:1009-3419
1999-6187
DOI:10.3779/j.issn.1009-3419.2016.08.10