缺血修饰清蛋白、胱抑素C及氨基末端脑钠肽前体对急性冠状动脉综合征的联合诊断价值

目的：探讨缺血修饰清蛋白（IMA）、胱抑素C（CysC）及氨基末端脑钠肽前体（NT-proBNP）对早期诊断急性冠状动脉综合征（acute coronary syndrome,ACS）的价值及其临床意义。方法：选择2015年6月至2016年6月在河南省胸科医院急诊科、心内科诊治的120例ACS患者（ACS组）及同期健康体检者50例（健康组）作为研究对象。比较两组血清IMA、CysC、NT-proBNP水平,并根据疾病诊断结果进行亚组分析。绘制受试者工作特征曲线（ROC）,分析IMA、CysC、NT-proBNP用于早期鉴别诊断ACS的价值。结果：ACS组IMA水平低于健康组（P〈0.05）;A...

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Bibliographic Details
Published in中国临床医学 Vol. 24; no. 3; pp. 416 - 419
Main Author 乔利阳 杜长春 周向东
Format Journal Article
LanguageChinese
Published 河南省胸科医院心血管外科,郑州,450000%河南省胸科医院急诊科,郑州,450000%河南省胸科医院心内科,郑州,450000 2017
Subjects
急性冠状动脉综合征
氨基末端脑钠肽前体
缺血修饰蛋白
胱抑素C
cystatin C
缺血修饰蛋白
ischemia modified protein
acute coronary syndrome
急性冠状动脉综合征
氨基末端脑钠肽前体
胱抑素C
N-terminal pro-brain natriuretic peptide
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ISSN1008-6358
DOI10.12025/j.issn.1008-6358.2017.20161006

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Summary:目的：探讨缺血修饰清蛋白（IMA）、胱抑素C（CysC）及氨基末端脑钠肽前体（NT-proBNP）对早期诊断急性冠状动脉综合征（acute coronary syndrome,ACS）的价值及其临床意义。方法：选择2015年6月至2016年6月在河南省胸科医院急诊科、心内科诊治的120例ACS患者（ACS组）及同期健康体检者50例（健康组）作为研究对象。比较两组血清IMA、CysC、NT-proBNP水平,并根据疾病诊断结果进行亚组分析。绘制受试者工作特征曲线（ROC）,分析IMA、CysC、NT-proBNP用于早期鉴别诊断ACS的价值。结果：ACS组IMA水平低于健康组（P〈0.05）;ACS组CysC、NT-proBNP水平高于健康组（P〈0.05）。ST段抬高型心肌梗死（STEMI）、非ST段抬高型心肌梗死（NSTEMI）、不稳定型心绞痛（UA）亚组患者的IMA水平差异无统计学意义;STEMI组NT-proBNP水平高于NSTEMI组（P〈0.05）;STEMI、NSTEMI组CysC、NT-proBNP、Gensini评分高于UA组（P〈0.05）。IMA＋CysC＋NT-proBNP诊断ACS的灵敏度为86.29%、特异度为92.33%、AUC值为0.912。结论：IMA＋CysC＋NT-proBNP联合诊断ACS有较高的临床价值。
Bibliography:Objective：To investigate the value of ischemia modified protein （IMA）, Cystatin C （CysC） and N-terminal pro-brain natriuretic peptide （NT-proBNP） in early diagnosis of acute coronary syndrome （ACS） and its clinical significance.Methods：120 patients with ACS （the ACS group） treated in the Department of Emergency or Cardiology of Henan Provincial Chest Hospital from June 2015 to June 2016 were selected, and a total of 50 healthy subjects （the healthy group） were also selected.The serum levels of IMA, CysC, and NT-proBNP were compared between the two groups, and the sub-group analysis was performed according to the results of disease diagnosis.The receiver operating characteristic curve （ROC） was used to analyze the diagnostic value of IMA, CysC, and NT-proBNP in early differential diagnosis of ACS.Results：The level of IMA in the ACS group was lower than that in the healthy group （P〈0.05）.The levels of CysC and NT-proBNP in the ACS group were higher than those in the healthy group （P〈0.05）.There was no significa
ISSN:1008-6358
DOI:10.12025/j.issn.1008-6358.2017.20161006