非酒精性脂肪性肝病的靶向治疗研究进展

非酒精性脂肪性肝病（NAFLD）是最常见的进行性疾病，临床上目前尚无疗效确切的治疗药物。介绍了脂肪酸-胆酸偶合物（FABACs）和熊去氧胆酸-溶血磷脂酰乙醇胺偶合物（UDCA-LPE）两种新型的具有NAFLD防治作用的肝靶向药物的研究进展。FABACs通过调节脂代谢，特异性的降低高脂饲料所致NAFLD的肝脏脂肪升高，预防NAFLD的形成；而且对已形成的NAFLD也有治疗作用；Ⅱ期临床研究结果显示其起效快、安全性好。UDCA-LPE在降低NAFLD的肝脏脂肪的同时，能够抑制线粒体损伤和凋亡，促进肝细胞再生，对NAFLD发展过程中的相关炎症具有显著的抑制作用。因此，FABACs和UDCA-LPE对...

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Bibliographic Details
Published in临床肝胆病杂志 Vol. 30; no. 5; pp. 469 - 472
Main Author 靳雪源（综述） 王慧芬（审校）
Format Journal Article
LanguageChinese
Published 解放军总医院和解放军医学院,北京,100853%解放军第302医院,北京,100039 2014
Subjects
熊去氧胆酸-溶血磷脂酰乙醇胺偶合物
综述
脂肪肝
脂肪酸-胆酸偶合物
脂肪肝
ursodeoxycholyl lysophosphatidylethanolamide
熊去氧胆酸-溶血磷脂酰乙醇胺偶合物
fatty acid bile acid conjugates
review
fatty liver
综述
脂肪酸-胆酸偶合物
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ISSN1001-5256
DOI10.3969/j.issn.1001-5256.2014.05.024

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Summary:非酒精性脂肪性肝病（NAFLD）是最常见的进行性疾病，临床上目前尚无疗效确切的治疗药物。介绍了脂肪酸-胆酸偶合物（FABACs）和熊去氧胆酸-溶血磷脂酰乙醇胺偶合物（UDCA-LPE）两种新型的具有NAFLD防治作用的肝靶向药物的研究进展。FABACs通过调节脂代谢，特异性的降低高脂饲料所致NAFLD的肝脏脂肪升高，预防NAFLD的形成；而且对已形成的NAFLD也有治疗作用；Ⅱ期临床研究结果显示其起效快、安全性好。UDCA-LPE在降低NAFLD的肝脏脂肪的同时，能够抑制线粒体损伤和凋亡，促进肝细胞再生，对NAFLD发展过程中的相关炎症具有显著的抑制作用。因此，FABACs和UDCA-LPE对防治NAFLD具有良好的应用前景。
Bibliography:fatty liver;fatty acid bile acid conjugates;ursodeoxycholyl lysophosphatidylethanolamide;review
Nonalcoholic fatty liver disease （NAFLD）is the most common progressive liver disease worldwide.Currently,there is no satisfying treatment for NAFLD.Research progress in fatty acid bile acid conjugates （FABACs）and ursodeoxycholyl lysophosphatidylethanolamide （UDCA-LPE）,which are two novel liver targeted drugs with anti-NAFLD effects,is reviewed.FABACs,which reduce liver fat in patients with NAFLD induced by high-fat diet by regulating lipid metabolism,have been proved effective in preventing and treating NAFLD. The safety and efficacy of FABACs in NAFLD patients have been confirmed in a phase II,randomized,double-blind,placebo-controlled trial.UDCA-LPE can not only reduce liver fat in NAFLD patients,but also inhibit mitochondrial damage and apoptosis and promote hepatocyte regeneration,with a marked anti-inflammatory effect during the development of NAFLD.Therefore,FABACs and UDCA-LPE hold promise for preventing and
ISSN:1001-5256
DOI:10.3969/j.issn.1001-5256.2014.05.024