军队某部干部糖调节受损者3年转归及其影响因素分析

目的 探讨军队某部体检干部糖调节受损人群的转归及其影响因素.方法 2012年6月至9月,军队某部1429名参加体检人群中筛选出糖调节受损(IGR)者并于2015年完成对其糖耐量状态的再评估.采用方差分析、Logistic回归进行统计学分析.结果 1429名体检人群中,IGR者共214例(15.0%),其中空腹血糖受损(IFG)52例(24.3%),糖耐量减低(IGT)113例(52.8%),IFG+IGT者49例(22.9%).3年后随访时,IGR受试者中转归为正常糖耐量者为78例(36.4%),仍为IGR者105例(49.1%),发展为糖尿病者共31例(14.5%).基线时IFG、IGT、I...

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Published in中华糖尿病杂志 Vol. 9; no. 7; pp. 440 - 445
Main Author 李琳 杜娟 吕进 李全民 胡晓强 杜瑞琴 朱艳秋 张秋兰 王爽 王利营
Format Journal Article
LanguageChinese
Published 解放军火箭军总医院内分泌科,北京,100088 2017
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ISSN1674-5809
DOI10.3760/cma.j.issn.1674-5809.2017.07.008

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Summary:目的 探讨军队某部体检干部糖调节受损人群的转归及其影响因素.方法 2012年6月至9月,军队某部1429名参加体检人群中筛选出糖调节受损(IGR)者并于2015年完成对其糖耐量状态的再评估.采用方差分析、Logistic回归进行统计学分析.结果 1429名体检人群中,IGR者共214例(15.0%),其中空腹血糖受损(IFG)52例(24.3%),糖耐量减低(IGT)113例(52.8%),IFG+IGT者49例(22.9%).3年后随访时,IGR受试者中转归为正常糖耐量者为78例(36.4%),仍为IGR者105例(49.1%),发展为糖尿病者共31例(14.5%).基线时IFG、IGT、IFG+IGT人员3年后的糖尿病累积发病率分别为11.5%、8.8%与30.6%(χ2=13.55,P=0.001).IFG+IGT发展为糖尿病的风险分别是IFG的1.8倍(OR=1.84,95%CI:1.090-3.102,P=0.022)和IGT的4.5倍(OR=4.54,95%CI:1.868-11.056,P=0.001).空腹血糖(OR=4.21,95%CI:1.937-9.155,P〈0.001)、餐后2 h血糖(OR=1.41,95%CI:1.024-2.027,P=0.036)、糖化血红蛋白(OR=10.30,95%CI:2.831-37.489,P〈0.001)分别为IGR发展为糖尿病的独立危险因素.当糖化血红蛋白≥5.7%时,3年内发展为糖尿病的风险是〈5.7%人群的5倍(OR=4.99,95%CI:1.837-13.538,P=0.002).结论 军队某部体检干部,IGR患病率低于一般人群,IFG+IGT发展为糖尿病风险较高,糖化血红蛋白可能为IGR向糖尿病转归的预测指标.
Bibliography:Li Lin, Du Juan, Lyu Jin, Li Quanmin, Hu Xiaoqiang, Du Ruiqin, Zhu Yanqiu, Zhang Qiulan, Wang Shuang, Wang Liying( Department of Endocrinology, the General Hospital of the PLA Rocket Force, Beijing 100088, China)
Objective To investigate the prognosis of impaired glucose regulation (IGR) in military officers and its risk factors. Methods Subjects with IGR was identified from 1429 military officers who underwent physical examination from June to September 2012, and were followed up by repeating glucose tolerance test in 2015. Variance, Chi-square test, rank sum test and Logistic regression were used for data analysis. Results A total of 214 subjects (15.0%) with IGR were identified from 1429 military officers, in which 52(24.3%) were found with impaired fasting glucose (IFG), 113(52.8%) with impaired glucose tolerance (IGT), and 49(22.9%) with IFG+IGT. After 3 years, 78(36.4%) subjects with IGR turned out to be normal, 105(49.1%) subjects remained to be IGR and 31(14.5%) subjects developed diabetes. The cumulat
ISSN:1674-5809
DOI:10.3760/cma.j.issn.1674-5809.2017.07.008