Supplement of bamboo extract lowers serum monocyte chemoattractant protein-1 concentration in mice fed a diet containing a high level of saturated fat

• Published in: British journal of nutrition Vol. 106; no. 12; pp. 1810 - 1813
• Main Authors: Higa, Jason K., Liu, Wanyu, Berry, Marla J., Panee, Jun
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 28.12.2011; CABI Pub
• Subjects: abdominal fat; administration & dosage; adverse effects; anatomy & histology; Animals; bamboos; Biological and medical sciences; Blood; blood serum; Body fat; Body weight; chemistry; Chemokine CCL2; Chemokine CCL2 - blood; chemokines; Diet; Diet, High-Fat; Diet, High-Fat - adverse effects; Dietary Supplements; drug effects; Ethanol; Feeding. Feeding behavior; food consumption; Fundamental and applied biological sciences. Psychology; Herbal medicine; high fat diet; Intra-Abdominal Fat; Intra-Abdominal Fat - anatomy & histology; Intra-Abdominal Fat - drug effects; Leukocytes; Male; Mice; Mice, Inbred C57BL; Molecular Nutrition; noninsulin-dependent diabetes mellitus; Organ Size; Organ Size - drug effects; Phyllostachys; Phyllostachys edulis; Plant Extracts; Plant Extracts - administration & dosage; Poaceae; Poaceae - chemistry; Proteins; Rodents; Vertebrates: anatomy and physiology, studies on body, several organs or systems; visceral fat; Monocyte chemoattractant protein-1; Bamboo extract; Mesenteric fat; High-fat diet; Monocyte; Rodentia; Lipids; Extract; Concentration; Saturated fat; Serum protein; Feeding; Vertebrata; Mammalia; Diet; Mouse; Saturated fatty acid; Animal; Fat
• ISSN: 0007-1145; 1475-2662; 1475-2662
• DOI: 10.1017/S0007114511002157

Monocyte chemoattractant protein-1 (MCP-1) is an inflammatory chemokine up-regulated in obese subjects, contributing to the development of type 2 diabetes. The present study investigated the inhibitory effect of an ethanol–water extract from bamboo (BEX, Phyllostachys edulis) on the blood concentration of MCP-1. C57BL/6J mice were fed a standard diet or a high-fat diet with or without the BEX supplement (11 g dry mass/17 000 kJ) for 6 months. A total of ten mice were used in each group. Body weight and food consumption were measured weekly. After euthanisation, the weight of visceral fat and circulating MCP-1 concentration were measured. In comparison with the standard control group, the high-fat control group had increased body weight, abdominal fat storage and serum MCP-1 concentration by 60 % (P < 0·001), 266 % (P < 0·001) and 180 % (P < 0·01), respectively. In comparison with the high-fat control group, the high-fat BEX group showed a 3 % decrease in body weight (P < 0·01), 24 % decrease in mesenteric fat depot (P < 0·01) and 49 % decrease in serum MCP-1 concentration (P < 0·05). The present study suggests that the BEX supplement in the high-fat diet ameliorates elevated MCP-1 concentrations in the blood, and whether this is related to modulated endocrine properties of the visceral fat is to be studied.