ADC值与肺癌组织学类型及分化程度的相关性研究
背景与目的肺癌的组织学类型和分化程度对于评估肿瘤的生物学行为、预后及选择治疗方式具有重要意义。本研究旨在探讨表观扩散系数(apparentdiffusioncoefficient,ADC)与肺癌组织学类型和分化程度的相关性。方法符合纳入标准的连续肺癌患者115例,行DWI检查(b=500s/mm2)并测量病变的ADC值,用t检验及单因素方差分析分析不同组织学类型及不同分化程度问ADC值的差异,用Spearman相关系数分析ADC值与不同分化程度之间的相关性。结果小细胞肺癌(smallcelllungcancer,SCLC)与非小细胞肺癌(non-small cell lungcancer,NS...
Saved in:
| Published in | 中国肺癌杂志 Vol. 15; no. 11; pp. 646 - 651 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
天津医科大学总医院放射科,天津,300052%徐州医学院附属医院放射科,徐州,221002
2012
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1009-3419 1999-6187 |
| DOI | 10.3779/j.issn.1009-3419.2012.11.01 |
Cover
| Summary: | 背景与目的肺癌的组织学类型和分化程度对于评估肿瘤的生物学行为、预后及选择治疗方式具有重要意义。本研究旨在探讨表观扩散系数(apparentdiffusioncoefficient,ADC)与肺癌组织学类型和分化程度的相关性。方法符合纳入标准的连续肺癌患者115例,行DWI检查(b=500s/mm2)并测量病变的ADC值,用t检验及单因素方差分析分析不同组织学类型及不同分化程度问ADC值的差异,用Spearman相关系数分析ADC值与不同分化程度之间的相关性。结果小细胞肺癌(smallcelllungcancer,SCLC)与非小细胞肺癌(non-small cell lungcancer,NSCLC)的ADC值差异有统计学意义(P=0.017),且SCLC与鳞癌、腺癌的ADC值差异均有统计学意义(p分别为0.011、0.001)。肺癌不同分化程度间的ADC值差异有统计学意义(P=0.003),且ADC值与病变不同分化程度存在相关性(rs=0.272,P=0.003)。结论ADC值对术前判断肺癌的组织学类型及分化程度有一定意义:小细胞肺癌的ADC值低,分化程度低的肿瘤的ADC值低。 |
|---|---|
| Bibliography: | Lung neoplasms; Diffusion-weighted imaging; Apparent diffusion coefficient; Magnetic resonance imaging Fei LI, Tielian YU, Weidong LI, Chong ZHANG, Yang CAO , Datong SU, Ying WANG, Dong LI (1.Department of Radiology,Tianjin Medical University General Hospital, Tianfin 300052, China; 2.Department of Radiology, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002,China) 12-1395/R Background and objective The histologic type and grade of lung cancer are significant in assessing the biological behaviour, prognosis and therapeutic regimen.This study investigates the correlation of apparent diffusion coefficient (ADC) with histologic type and grade of lung cancer. Methods A total of 115 patients pathologically diagnosed with lung cancer were enrolled in this study. Magnetic resonance (MR)-DWI with a diffusion factor of 500 s/mm2 was performed and the ADC values of lesions were measured. The ADC values among the different histologic types and grades were compared with the values obtained using t-test and one-wa |
| ISSN: | 1009-3419 1999-6187 |
| DOI: | 10.3779/j.issn.1009-3419.2012.11.01 |