Rho蛋白家族与乳腺癌关系的研究进展

乳腺癌是导致妇女死亡的主要原因之一，其发病率具有逐年上升的趋势。RhoGTP酶及其调节蛋白和效应物均在促进乳腺癌的发生以及远处转移的过程中发挥着重要作用。本文分别从RhoGTP酶及其调节蛋白和效应物对乳腺癌发生及发展的调控作用和如何针对RhoGTP酶通路进行乳腺癌的靶向治疗等方面进行综述。...

Full description

Saved in:
Bibliographic Details
Published in天津医药 Vol. 45; no. 7; pp. 777 - 780
Main Author 郑霞;刘冰冰;孟凡凡;李帅;谷峰;付丽
Format Journal Article
LanguageChinese
Published 天津医科大学肿瘤医院乳腺病理研究室,国家肿瘤临床医学研究中心,天津市“肿瘤防治”重点实验室,天津市恶性肿瘤临床医学研究中心,乳腺癌防治教育部重点实验室 300060 2017
Subjects
乳腺肿瘤;肿瘤转移;GTP结合蛋白质类;RhoGTP酶;调节蛋白;GTP酶效应物;靶向治疗
targeted therapy
GTP结合蛋白质类
GTP-binding proteins
breast neoplasms
肿瘤转移
GTP酶效应物
regulatory proteins
Rho GTP酶
调节蛋白
乳腺肿瘤
Rho GTPases
靶向治疗
neoplasm metastasis
Rho GTPases effectors
Online AccessGet full text
ISSN0253-9896
DOI10.11958/20170580

Cover

More Information
Summary:乳腺癌是导致妇女死亡的主要原因之一，其发病率具有逐年上升的趋势。RhoGTP酶及其调节蛋白和效应物均在促进乳腺癌的发生以及远处转移的过程中发挥着重要作用。本文分别从RhoGTP酶及其调节蛋白和效应物对乳腺癌发生及发展的调控作用和如何针对RhoGTP酶通路进行乳腺癌的靶向治疗等方面进行综述。
Bibliography:Breast cancer is one of the major causes of death in women,and its incidence has been increasing year after year.The Rho GTPases,their regulatory proteins and Rho GTPases play an important role in promoting the occurrence and distant metastasis of breast cancer.Here we summarized the current knowledge of the regulation network of Rho GTPases,their regulatory proteins and Rho GTPases on the occurrence and development of breast cancer,and targeted therapy for RHO GTP enzyme pathway in breast cancer.
breast neoplasms; neoplasm metastasis; GTP-binding proteins; Rho GTPases; regulatory proteins; Rho GTPases effectors; targeted therapy
12-1116/R
ISSN:0253-9896
DOI:10.11958/20170580