Lower oxygen saturation with higher rates of norepinephrine in bone fractures of polytrauma patients: a pilot study

• Published in: Critical care (London, England) Vol. 27; no. 1; pp. 1 - 3
• Main Authors: Koch, Laura, Orth, Marcel, Fink, Tobias, Meiser, Andreas, Volk, Thomas, Menger, Michael D., Laschke, Matthias W., Pastor, Torsten, Knobe, Matthias, Pohlemann, Tim, Ganse, Bergita
• Format: Journal Article
• Language: English
• Published: London BioMed Central 25.09.2023; BioMed Central Ltd; BMC
• Subjects: Blood pressure; Catecholamines; Correspondence; Critical care; Critical Care Medicine; Emergency Medicine; Fracture healing; Fractures; Hemoglobin; Intensive; Intensive care; Lasers; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Microcirculation; Multiple trauma; Non-union; Noradrenaline; Oxygen saturation; Pharmacists; Pilot projects; Statistics; Trauma; Trauma Care for the 21st Century; Microcirculation; O2C; Multiple trauma; Perfusion; Injury; Non-union; Catecholamines; Fracture healing; Mean arterial pressure; Noradrenaline
• ISSN: 1364-8535; 1466-609X; 1364-8535; 1366-609X; 1466-609X
• DOI: 10.1186/s13054-023-04657-6

In a pilot trial, we used the laser-Doppler device ‘Oxygen to see’ (O2C, LEA Medizintechnik, Winchesterstr. 2, D-35394 Gießen, Germany) to measure SO2, haemoglobin (Hb), and blood flow (BF) in 3, 10, and 14/16 mm depth in four tibial and clavicle fractures of three patients with multiple injuries who received NE. In 3 mm, up to 14.7% of the variability could be explained by MAP alone, and in 14/16 mm, up to 13.5% by NE alone. [...]only NE and not MAP had an effect on SO2 in 14/16 mm depth inside the fractures. Effect of early use of noradrenaline on in-hospital mortality in haemorrhagic shock after major trauma: a propensity-score analysis.