Non-alcoholic fatty liver disease and compromised endothelial function in people with type 2 diabetes

• Published in: BMC endocrine disorders Vol. 23; no. 1; pp. 1 - 6
• Main Authors: Montazeri, Zeinab, Hashemi-Madani, Nahid, Iraji, Hamed, Sohrabi, Masoudreza, Alaei-Shahmiri, Fariba, Emami, Zahra, Babaei, Mohammad Reza, Malek, Mojtaba, Khamseh, Mohammad E.
• Format: Journal Article
• Language: English
• Published: London BioMed Central 25.09.2023; BioMed Central Ltd; BMC
• Subjects: Analysis; Arteriosclerosis; Atherosclerosis; Body mass index; Cardiovascular disease; Development and progression; Diabetes; Diabetes mellitus (non-insulin dependent); Disease susceptibility; Endocrinology; Endothelial dysfunction; Endothelium; Fatty liver; Flow-mediated dilation; Hepatitis; Hypertension; Insulin resistance; Laboratories; Liver diseases; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Metabolic Diseases; Metabolic disorders; Metabolic syndrome; Multivariate analysis; Non-alcoholic fatty liver disease; Oxidative stress; Population; Risk factors; rology; Type 2 diabetes; Ultrasonic imaging; Veins & arteries; Womens health; Type 2 diabetes; Endothelial dysfunction; Cardiovascular disease; Flow-mediated dilation; Non-alcoholic fatty liver disease
• ISSN: 1472-6823; 1472-6823
• DOI: 10.1186/s12902-023-01460-w

Introduction Nonalcoholic fatty liver disease (NAFLD) frequently coexists with type 2 diabetes mellitus (T2DM) and synergistically contributes to the development of atherosclerosis. Flow-mediated dilation (FMD) is a commonly used noninvasive test for assessing endothelial function. The main objective of this study was to explore FMD in patients with T2DM with and without NAFLD. Methods In this cross-sectional study, conducted on people with T2DM, NAFLD was defined as controlled attenuation parameter (CAP) score > 302 dB/m. Endothelial dysfunction was detected when arterial FMD of brachial artery was equal or less than 0.7%. Regression analyses were applied to assess factors associated with impaired FMD. Result A total of 147 patients (72 with NAFLD and 75 without NAFLD) were included in the final analysis. Patients with NAFLD were more likely to develop FMD ≤ 7% (77.8% vs. 58.7%, P = 0.01). In multivariate analysis, NAFLD (OR = 2.581, 95% CI (1.18–5.62), P = 0.017) and hypertension (HTN) (OR = 3.114, 95% CI (1.31–7.35), P = 0.010) were associated with an increased risk of impaired FMD. However, female sex was associated with a decreased risk of impaired FMD (OR = 0.371, 95% CI (0.15–0.87), P = 0.024). Conclusion NAFLD is associated with endothelial dysfunction in people with T2DM. This risk is comparable with the risk imposed by HTN, highlighting the importance of screening and management of NAFLD in these patients.