Pathological-Condition-Driven Construction of Supramolecular Nanoassemblies for Bacterial Infection Detection

• Published in: Advanced materials (Weinheim) Vol. 28; no. 2; pp. 254 - 262
• Main Authors: Li, Li-Li, Ma, Huai-Lei, Qi, Guo-Bin, Zhang, Di, Yu, Faquan, Hu, Zhiyuan, Wang, Hao
• Format: Journal Article
• Language: English
• Published: Germany Blackwell Publishing Ltd 13.01.2016
• Subjects: Animals; Bacteria; bacterial infection; Bacterial Infections - complications; Bacterial Infections - diagnosis; Bacterial Infections - physiopathology; bioimaging; Chlorophyll - analogs & derivatives; Chlorophyll - chemical synthesis; Chlorophyll - chemistry; Construction; Construction specifications; Contrast Media - chemical synthesis; Contrast Media - chemistry; Diagnosis; Disease Models, Animal; Escherichia coli; Gelatinases - chemistry; Mice; Models, Biological; Molecular Structure; Myositis - complications; Myositis - diagnosis; Myositis - physiopathology; nanomaterials; Nanostructure; Nanostructures - chemistry; peptides; Phantoms, Imaging; Photoacoustic effect; Photoacoustic Techniques - methods; Proteus vulgaris; Staphylococcus aureus; Staphylococcus epidermidis; Superstructures; supramolecular; Tomography; Tomography - methods; Vancomycin - analogs & derivatives; Vancomycin - chemical synthesis; Vancomycin - chemistry; Water - chemistry; peptides; supramolecular; nanomaterials; bacterial infection; bioimaging
• ISSN: 0935-9648; 1521-4095
• DOI: 10.1002/adma.201503437

A pyropheophorbide‐α‐based building block (Ppa‐PLGVRG‐Van) can be used to construct self‐aggregated superstructures in vivo for highly specific and sensitive diagnosis of bacterial infection by noninvasive photoacoustic tomography. This in vivo supramolecular chemistry approach opens a new avenue for efficient, rapid, and early‐stage disease diagnosis with high sensitivity and specificity.