Cross-over assessment of serum bactericidal activity of moxifloxacin and levofloxacin versus penicillin-susceptible and penicillin-resistant Streptococcus pneumoniae in healthy volunteers

• Published in: Diagnostic microbiology and infectious disease Vol. 58; no. 3; pp. 375 - 378
• Main Authors: Hart, Daniel, Weinstein, Melvin P.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.07.2007; Elsevier
• Subjects: Adolescent; Adult; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - pharmacokinetics; Anti-Bacterial Agents - pharmacology; Aza Compounds - administration & dosage; Aza Compounds - pharmacokinetics; Aza Compounds - pharmacology; Bacteria; Bacteriology; Biological and medical sciences; Female; Fluoroquinolones; Fundamental and applied biological sciences. Psychology; Humans; Infectious Disease; Internal Medicine; Levofloxacin; Male; Microbiology; Miscellaneous; Moxifloxacin; Ofloxacin - administration & dosage; Ofloxacin - pharmacokinetics; Ofloxacin - pharmacology; Penicillin Resistance; Quinolines - administration & dosage; Quinolines - pharmacokinetics; Quinolines - pharmacology; Serum bactericidal activity; Serum Bactericidal Test; Streptococcus pneumoniae; Streptococcus pneumoniae - drug effects; Levofloxacin; Moxifloxacin; Serum bactericidal activity; Streptococcus pneumoniae; β-Lactams; Penicillin derivatives; Resistance; Streptococcaceae; Fluoroquinolone derivatives; Bacteria; Micrococcales; Serum; Antibacterial agent; Quinolone derivatives
• ISSN: 0732-8893; 1879-0070
• DOI: 10.1016/j.diagmicrobio.2007.02.006

We compared the serum bactericidal activity (SBA) of moxifloxacin and levofloxacin against penicillin-susceptible and penicillin-resistant Streptococcus pneumoniae in 12 healthy volunteers. Each subject received 3 days of oral moxifloxacin 400 mg daily and levofloxacin 750 mg daily, respectively, with a 2- to 4-week washout period between regimens. Blood was drawn at 6 time points after the third dose of each antibiotic. Mean serum bactericidal titers (MSBTRs) for moxifloxacin were 4-fold higher than the mean titers for levofloxacin at each time point. For each drug, MSBTRs at each time point were the same or within one 2-fold dilution when analyzed according to the penicillin susceptibility of the strains or the sex of the subjects. The difference in SBA of the 2 drugs may have implications for the emergence of resistance and clinical outcome.