脑源性神经营养因子血清浓度与双相障碍关系横断面研究
背景近年来发现,脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)的血清浓度与双相障碍症状关系的研究结果不一致。目的检验BDNF血清浓度与双相障碍的关系,并讨论双相障碍家族史在两者关系中的作用。方法检测了228例双相障碍患者和153名健康对照者的BDNF血清浓度,采用杨氏躁狂量表和汉密尔顿抑郁量表(17项)评估患者的躁狂或抑郁症状,将杨氏躁狂量表评分≥20分定义为躁狂发作,共计85例;将汉密尔顿抑郁量表评分≥17分定义为抑郁发作,共计14例;将杨氏躁狂量表评分〈20分并且汉密尔顿抑郁量表评分〈17分定义为缓解期,共计129例。结果患者组平均(标准...
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Published in | 上海精神医学 Vol. 23; no. 4; pp. 207 - 213 |
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Main Author | |
Format | Journal Article |
Language | Chinese |
Published |
复旦大学附属中山医院医学心理科,200032%上海交通大学医学院附属精神卫生中心,200030%复旦大学附属华山医院精神医学科,200040
2011
复旦大学附属华山医院精神医学科,200040 |
Subjects | |
Online Access | Get full text |
ISSN | 1002-0829 |
DOI | 10.3969/j.issn.1002-0829.2011.04.003 |
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Summary: | 背景近年来发现,脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)的血清浓度与双相障碍症状关系的研究结果不一致。目的检验BDNF血清浓度与双相障碍的关系,并讨论双相障碍家族史在两者关系中的作用。方法检测了228例双相障碍患者和153名健康对照者的BDNF血清浓度,采用杨氏躁狂量表和汉密尔顿抑郁量表(17项)评估患者的躁狂或抑郁症状,将杨氏躁狂量表评分≥20分定义为躁狂发作,共计85例;将汉密尔顿抑郁量表评分≥17分定义为抑郁发作,共计14例;将杨氏躁狂量表评分〈20分并且汉密尔顿抑郁量表评分〈17分定义为缓解期,共计129例。结果患者组平均(标准差)BDNF血清浓度低于健康对照组[18.75(8.98)ng/d比23.72(5.60).g/ml,t=6.09,P〈0.001】,且各个亚组(躁狂组、抑郁组和缓解期组)与健康对照组BDNF血清浓度的差异均有统计学意义。躁狂发作期与缓解期之间的BDNF血清浓度差异有统计学意义,其余各亚组间的差异无统计学意义。在多元线性回归模型中控制各个因素后,发现仅有杨氏躁狂量表评分与BDNF血清浓度呈正相关(标准回归系数=0.17,P=0.011)。结论双相障碍患者的BDNF血清浓度低于健康对照组,BDNF血清浓度与躁狂症状存在正相关,与是否存在家族史并不相关。 |
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Bibliography: | 31-1564/R Background: Recent studies have reached different conclusions about the relationship of brain-derived neurotrophic factor (BDNF) and the symptoms of bipolar disorder.Objective: Examine the correlation between the serum concentration of 13DNF and bipolar disorder and consider whether or not family history of bipolar disorder mediates this relationship.Methods: Serum BDNF concentrations were measured in 228 patients with bipolar disorder and 153 normal con- trols. Patients with bipolar disorder were assessed using the Young Mania Rating Scale (YMRS) and the Hamilton Depression Rating Scale (HAMD-I 7):85 with YMRS~〉20 were considered manic, 14 with HAMD≥ 17 were considered depressed, and 129 with YMRS 〈20 and HAMD 〈 17 were considered euthymic.Results: The mean (SD) concentration of BDNF in bipolar patients was significantly lower than that in the control group [ 18.75 (8.98) ng/ml vs. 23.72(5.60) ng/ml; t=6.09, P 〈0. 001 ], and this difference was present persisted in all three phases of bipolar illnes |
ISSN: | 1002-0829 |
DOI: | 10.3969/j.issn.1002-0829.2011.04.003 |