轻度认知障碍工作记忆中theta 振荡的特征研究

目的探讨轻度认知障碍（MCI）患者工作记忆（WM）障碍theta振荡的特征模式。方法选取2016年1月—11月就诊于天津医科大学总医院的MCI患者（MCI组）和健康体检者（对照组）各15例。比较2组受试者执行视觉工作记忆任务的行为学差异。同步采集34通道脑电信号，应用短时傅里叶变换进行多通道脑电信号的能量空间分布、时频分布和频谱相干分析。结果与对照组相比，在工作记忆行为学方面，MCI组的反应时间明显延长，正确率明显下降，差异均有统计学意义（P＜0.01）。脑电信号分析显示2组在额中线Fz通道的theta振荡能量最大，但MCI组额区theta振荡能量密度较对照组明显减低（P＜0.01），额区内部...

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Bibliographic Details
Published in天津医药 Vol. 45; no. 6; pp. 605 - 609
Main Author 李花娟;朱婧;宋毅军;张挺
Format Journal Article
LanguageChinese
Published 天津医科大学总医院神经内科 300052%天津医科大学生物医学工程与技术学院 2017
Subjects
振荡;多通道脑电信号
轻度认知障碍;工作记忆;theta
theta oscillation
multi-channel electroencephalographs
工作记忆
轻度认知障碍
working memory
多通道脑电信号
mild cognitive impairment
theta振荡
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ISSN0253-9896
DOI10.11958/20170091

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Summary:目的探讨轻度认知障碍（MCI）患者工作记忆（WM）障碍theta振荡的特征模式。方法选取2016年1月—11月就诊于天津医科大学总医院的MCI患者（MCI组）和健康体检者（对照组）各15例。比较2组受试者执行视觉工作记忆任务的行为学差异。同步采集34通道脑电信号，应用短时傅里叶变换进行多通道脑电信号的能量空间分布、时频分布和频谱相干分析。结果与对照组相比，在工作记忆行为学方面，MCI组的反应时间明显延长，正确率明显下降，差异均有统计学意义（P＜0.01）。脑电信号分析显示2组在额中线Fz通道的theta振荡能量最大，但MCI组额区theta振荡能量密度较对照组明显减低（P＜0.01），额区内部及额-后部脑区之间theta振荡的同步性明显下降（P＜0.05）。结论MCI患者额区theta振荡的缺失可能是其WM障碍的重要机制之一。
Bibliography:mild cognitive impairment; working memory; theta oscillation; multi-channel electroencephalographs
Objective To study the feature of theta oscillation during working memory(WM)dysfunction in patientswith mild cognitive impairment(MCI).Methods Fifteen MCI patients(MCI group)and15healthy subjects for checkup(control group)in Tianjin Medical University General Hospital from January to November2016were recruited.Thedifferences of behavioral results in visual WM tasks were compared between the two groups.Thirty four-channelelectroencephalogram(EEG)signals were recorded simultaneously.Short-Time Fourier transform was used to calculatespatial and time-frequency distribution of power and spectral coherence of multi-channel EEGs.Results Compared withcontrol group,MCI group showed significantly longer reaction time and lower accuracy in WM tasks(P<0.01).The analysisof EEGs revealed that the power of Fz channel was the biggest at frontal midline in both groups.And the power density oftheta oscillation was lower at fro
ISSN:0253-9896
DOI:10.11958/20170091