In vivo kinematical validated knee model for preclinical testing of total knee replacement

• Published in: Computers in biology and medicine Vol. 132; p. 104311
• Main Authors: Shu, Liming, Yao, Jiang, Yamamoto, Ko, Sato, Takashi, Sugita, Naohiko
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.05.2021; Elsevier Limited
• Subjects: Boundary conditions; Computer applications; Constraint modelling; Contact pressure; Contact stresses; Design; Electromyography; Experimental validation; Finite element; Finite element method; Fitness equipment; Fluoroscopy; Force; Gait; In vivo methods and tests; Internal Medicine; Joints (anatomy); Kinematics; Knee; Knee kinematics; Knee model; Ligaments; Mathematical models; Mechanics; Model matching; Model testing; Motion capture; Other; Patients; Proportional integral derivative; Prostheses; Quadriceps muscle; Rotation; Soft tissues; Surgical implants; Total knee replacement; Translation; United States > US; Kansas; Knee kinematics; Experimental validation; Knee model; Total knee replacement; Finite element
• ISSN: 0010-4825; 1879-0534; 1879-0534
• DOI: 10.1016/j.compbiomed.2021.104311

A computational knee model facilitates efficient component design evaluations and preclinical testing under various dynamic loadings. However, the development of a highly mimicked dynamic whole knee model with specified ligament constraints that provides high predictive accuracy with in-vivo experiments remains a challenge. In the present study, a musculoskeletal integrated force-driven explicit finite-element knee model with tibiofemoral and patellofemoral joints constrained with detailed soft tissue was developed. A proportional-integral-derivative controller was concurrently added to the knee model to track the boundary conditions. The actuations of the quadriceps and hamstrings were predicted via a subject-specific musculoskeletal model and matched with electromyography results. Compared to in-vivo fluoroscopic results in a gait cycle, the predicted results of the kinematics of the tibiofemoral joint exhibited an agreement in terms of tendency and magnitude (anterior–posterior translation: RMSE = 1.1 mm, r2 = 0.87; inferior–superior translation: RMSE = 0.83 mm, r2 = 0.84; medial–lateral translation: RMSE = 0.82 mm, r2 = 0.05; flexion–extension rotation: RMSE = 0.23°, r2 = 1; internal-external rotation: RMSE = 1.85°, r2 = 0.65; varus–valgus rotation: RMSE = 1.39°, r2 = 0.08). Contact mechanics, including the contact area, pressure, and stress, were synchronously simulated on the tibiofemoral and patellofemoral joints. The study provides a calibrated knee model and a kinematical validation approach that can be widely used in preclinical testing and knee prosthesis design. •A musculoskeletal integrated force-driven finite element knee model was developed and verified by experiments.•The predicted results of kinematics of the tibiofemoral joint exhibited an agreement with in-vivo fluoroscopic results.•Contact mechanics including the contact area, pressure, and stress can be synchronously simulated by the proposed knee model.