Impact of repetitive transcranial magnetic stimulation on cortical activity: a systematic review and meta-analysis utilizing functional near-infrared spectroscopy evaluation

• Published in: Journal of neuroengineering and rehabilitation Vol. 21; no. 1; pp. 108 - 14
• Main Authors: Chen, Shao-Yu, Tsou, Meng-Hsuan, Chen, Kuan-Yu, Liu, Yan-Ci, Lin, Meng-Ting
• Format: Journal Article
• Language: English
• Published: London BioMed Central 24.06.2024; BioMed Central Ltd; BMC
• Subjects: Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Cortical excitability; Cortical hemodynamics; Functional near-infrared spectroscopy (fNIRS); Health aspects; Hemodynamics; Humans; Infrared spectroscopy; Magnetic brain stimulation; Motor cortex; Motor Cortex - diagnostic imaging; Motor Cortex - physiology; Neurological research; Neurology; Neurosciences; Physiological aspects; Primary motor cortex; Rehabilitation Medicine; Repeated transcranial magnetic stimulation (rTMS); Review; Spectroscopy, Near-Infrared - methods; Testing; Transcranial Magnetic Stimulation - methods; Taiwan; Primary motor cortex; Cortical excitability; Repeated transcranial magnetic stimulation (rTMS); Functional near-infrared spectroscopy (fNIRS); Cortical hemodynamics
• ISSN: 1743-0003; 1743-0003
• DOI: 10.1186/s12984-024-01407-9

Background Repeated transcranial magnetic stimulation (rTMS) could induce alterations in cortical excitability and promote neuroplasticity. To precisely quantify these effects, functional near-infrared spectroscopy (fNIRS), an optical neuroimaging modality adept at detecting changes in cortical hemodynamic responses, has been employed concurrently alongside rTMS to measure and tailor the impact of diverse rTMS protocols on the brain cortex. Objective This systematic review and meta-analysis aimed to elucidate the effects of rTMS on cortical hemodynamic responses over the primary motor cortex (M1) as detected by fNIRS. Methods Original articles that utilized rTMS to stimulate the M1 cortex in combination with fNIRS for the assessment of cortical activity were systematically searched across the PubMed, Embase, and Scopus databases. The search encompassed records from the inception of these databases up until April, 2024. The assessment for risk of bias was also conducted. A meta-analysis was also conducted in studies with extractable raw data. Results Among 312 studies, 14 articles were eligible for qualitative review. 7 studies were eligible for meta-analysis. A variety of rTMS protocols was employed on M1 cortex. In inhibitory rTMS, multiple studies observed a reduction in the concentration of oxygenated hemoglobin [HbO] at the ipsilateral M1, contrasted by an elevation at the contralateral M1. Meta-analysis also corroborated this consistent trend. Nevertheless, certain investigations unveiled diminished [HbO] in bilateral M1. Several studies also depicted intricate inhibitory or excitatory interplay among distinct cortical regions. Conclusion Diverse rTMS protocols led to varied patterns of cortical activity detected by fNIRS. Meta-analysis revealed a trend of increasing [HbO] in the contralateral cortices and decreasing [HbO] in the ipsilateral cortices following low frequency inhibitory rTMS. However, due to the heterogeneity between studies, further research is necessary to comprehensively understand rTMS-induced alterations in brain activity.