上皮间质转化与肿瘤耐药

肿瘤药物治疗过程中常常要面临肿瘤细胞耐药的问题。上皮间质转化（epithelial-mesenchymal transition,EMT）在肿瘤耐药方面的作用为解决该问题提供了可能。该文围绕EMT基本特征、EMT与肿瘤耐药的关系、EMT在肿瘤耐药过程中机制的研究进展进行详细综述。...

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Bibliographic Details
Published in中国肺癌杂志 Vol. 16; no. 1; pp. 54 - 57
Main Author 张琳琳 吴志浩 周清华
Format Journal Article
LanguageChinese
Published 300052天津,天津市肺癌转移与肿瘤微环境重点实验室,天津市肺癌研究所,天津医科大学总医院 2013
天津医科大学总医院肿瘤科
Subjects
上皮间质转化
耐药
肿瘤
肿瘤
上皮间质转化
耐药
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ISSN1009-3419
1999-6187
DOI10.3779/j.issn.1009-3419.2013.01.10

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Summary:肿瘤药物治疗过程中常常要面临肿瘤细胞耐药的问题。上皮间质转化（epithelial-mesenchymal transition,EMT）在肿瘤耐药方面的作用为解决该问题提供了可能。该文围绕EMT基本特征、EMT与肿瘤耐药的关系、EMT在肿瘤耐药过程中机制的研究进展进行详细综述。
Bibliography:Linlin ZHANG1＇2, Zhihao WU1, Ojnghua ZHOU1 Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China; 2Department of Oncology, Tianjin Medical University General Hospital, Tianjin 300052, China
[ Abstract ] Resistance to antineoplastic drugs is a common problem in cancer treatments. Epithelial-mesenchymal transition （EMT）, which plays an important role in the process of drug resistance, may provide opportunity to solve this prob- lem. ＂Ihis article reviews the characteristics of EMT, relationship between EMT and drug resistance, mechanism of EMT in tumor drug resistance in details.
Epithelial-mesenchymal transition; Tumor; Drug resistance
12-1395/R
ISSN:1009-3419
1999-6187
DOI:10.3779/j.issn.1009-3419.2013.01.10