Isoflavone aglycon produced by culture of soybean extracts with basidiomycetes and its anti-angiogenic activity
Soybean extracts (SBE) containing isoflavone glycosides were cultured with Ganoderma lucidum mycelia producing β-glucosidase. The anti-angiogenic effects of the cultivated product, containing rich in genistein, named GCP (genistein combined polysaccharide), were assessed with chick chorioallantoic m...
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| Published in | Bioscience, biotechnology, and biochemistry Vol. 66; no. 12; pp. 2626 - 2631 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Tokyo
Japan Society for Bioscience, Biotechnology, and Agrochemistry
01.12.2002
Japan Society for Bioscience Biotechnology and Agrochemistry Oxford University Press |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0916-8451 1347-6947 1347-6947 |
| DOI | 10.1271/bbb.66.2626 |
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| Abstract | Soybean extracts (SBE) containing isoflavone glycosides were cultured with Ganoderma lucidum mycelia producing β-glucosidase. The anti-angiogenic effects of the cultivated product, containing rich in genistein, named GCP (genistein combined polysaccharide), were assessed with chick chorioallantoic membranes (CAM) and a mouse dorsal air-sac model. β-Glucosidase produced by the mycelia converted the isoflavone glycosides into aglycons. A test of volunteers showed that serum concentrations of genistein in the subjects treated with GCP (n=4) at 3 h after administration were significantly higher than those in the subjects treated with SBE (n=4).
GCP inhibited angiogenesis in CAM, and the activity of GCP was greater than that of SBE. GCP inhibited the formation of new vessels induced by colon carcinoma cells in vivo. |
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| AbstractList | Soybean extracts (SBE) containing isoflavone glycosides were cultured with Ganoderma lucidum mycelia producing β-glucosidase. The anti-angiogenic effects of the cultivated product, containing rich in genistein, named GCP (genistein combined polysaccharide), were assessed with chick chorioallantoic membranes (CAM) and a mouse dorsal air-sac model. β-Glucosidase produced by the mycelia converted the isoflavone glycosides into aglycons. A test of volunteers showed that serum concentrations of genistein in the subjects treated with GCP (n=4) at 3 h after administration were significantly higher than those in the subjects treated with SBE (n=4). GCP inhibited angiogenesis in CAM, and the activity of GCP was greater than that of SBE. GCP inhibited the formation of new vessels induced by colon carcinoma cells in vivo. Soybean extracts (SBE) containing isoflavone glycosides were cultured with Ganoderma lucidum mycelia producing beta -glucosidase. The anti-angiogenic effects of the cultivated product, containing rich in genistein, named GCP (genistein combined polysaccharide), were assessed with chick choiroallantoic membranes (CAM) and a mouse dorsal air-sac model. beta -Glucosidase produced by the mycelia converted the isoflavone glycosides into aglycons. A test of volunteers showed that serum concentrations of genistein in the subjects treated with GCP (n=4) at 3 h after administration were significantly higher than those in the subjects treated with SBE (n=4). GCP inhibited angiogenesis in CAM, and the activity of GCP was greater than that of SBE. GCP inhibited the formation of new vessels induced by colon carcinoma cells in vivo. Soybean extracts (SBE) containing isoflavone glycosides were cultured with Ganoderma lucidum mycelia producing beta-glucosidase. The anti-angiogenic effects of the cultivated product, containing rich in genistein, named GCP (genistein combined polysaccharide), were assessed with chick chorioallantoic membranes (CAM) and a mouse dorsal air-sac model. Beta-glucosidase produced by the mycelia converted the isoflavone glycosides into aglycons. A test of volunteers showed that serum concentrations of genistein in the subjects treated with GCP (n = 4) at 3 h after administration were significantly higher than those in the subjects treated with SBE (n = 4). GCP inhibited angiogenesis in CAM, and the activity of GCP was greater than that of SBE. GCP inhibited the formation of new vessels induced by colon carcinoma cells in vivo. Soybean extracts (SBE) containing isoflavone glycosides were cultured with Ganoderma lucidum mycelia producing beta-glucosidase. The anti-angiogenic effects of the cultivated product, containing rich in genistein, named GCP (genistein combined polysaccharide), were assessed with chick chorioallantoic membranes (CAM) and a mouse dorsal air-sac model. Beta-glucosidase produced by the mycelia converted the isoflavone glycosides into aglycons. A test of volunteers showed that serum concentrations of genistein in the subjects treated with GCP (n = 4) at 3 h after administration were significantly higher than those in the subjects treated with SBE (n = 4). GCP inhibited angiogenesis in CAM, and the activity of GCP was greater than that of SBE. GCP inhibited the formation of new vessels induced by colon carcinoma cells in vivo.Soybean extracts (SBE) containing isoflavone glycosides were cultured with Ganoderma lucidum mycelia producing beta-glucosidase. The anti-angiogenic effects of the cultivated product, containing rich in genistein, named GCP (genistein combined polysaccharide), were assessed with chick chorioallantoic membranes (CAM) and a mouse dorsal air-sac model. Beta-glucosidase produced by the mycelia converted the isoflavone glycosides into aglycons. A test of volunteers showed that serum concentrations of genistein in the subjects treated with GCP (n = 4) at 3 h after administration were significantly higher than those in the subjects treated with SBE (n = 4). GCP inhibited angiogenesis in CAM, and the activity of GCP was greater than that of SBE. GCP inhibited the formation of new vessels induced by colon carcinoma cells in vivo. Soybean extracts (SBE) containing isoflavone glycosides were cultured with Ganoderma lucidum mycelia producing β-glucosidase. The anti-angiogenic effects of the cultivated product, containing rich in genistein, named GCP (genistein combined polysaccharide), were assessed with chick chorioallantoic membranes (CAM) and a mouse dorsal air-sac model. β-Glucosidase produced by the mycelia converted the isoflavone glycosides into aglycons. A test of volunteers showed that serum concentrations of genistein in the subjects treated with GCP (n=4) at 3 h after administration were significantly higher than those in the subjects treated with SBE (n=4). GCP inhibited angiogenesis in CAM, and the activity of GCP was greater than that of SBE. GCP inhibited the formation of new vessels induced by colon carcinoma cells in vivo. |
| Author | Yoshida, M Miura, T. (Amino Up Chemical Co. Ltd., Sapporo (Japan)) Kosuna, K Yuan, L Sun, B Fujii, H Wakame, K |
| Author_xml | – sequence: 1 fullname: Miura, T. (Amino Up Chemical Co. Ltd., Sapporo (Japan)) – sequence: 2 fullname: Yuan, L – sequence: 3 fullname: Sun, B – sequence: 4 fullname: Fujii, H – sequence: 5 fullname: Yoshida, M – sequence: 6 fullname: Wakame, K – sequence: 7 fullname: Kosuna, K |
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| Keywords | Cell culture isoflavone aglycon Basidiomycetes Extract Soybean Isoflavone derivatives Fungi genistein Glycoside Aves Antiangiogenic agent Ganoderma Thallophyta Reaction product angiogenesis Rodentia β-glucosidase In vitro Biological activity Hydrolysis Vertebrata Mammalia Mouse Animal Plant origin Chicken |
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| Snippet | Soybean extracts (SBE) containing isoflavone glycosides were cultured with Ganoderma lucidum mycelia producing β-glucosidase. The anti-angiogenic effects of... Soybean extracts (SBE) containing isoflavone glycosides were cultured with Ganoderma lucidum mycelia producing beta-glucosidase. The anti-angiogenic effects of... Soybean extracts (SBE) containing isoflavone glycosides were cultured with Ganoderma lucidum mycelia producing beta -glucosidase. The anti-angiogenic effects... |
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| SubjectTerms | Adult aglycons Air Sacs - blood supply Air Sacs - drug effects angiogenesis Angiogenesis Inhibitors - chemistry Angiogenesis Inhibitors - pharmacology Angiogenesis Inhibitors - therapeutic use Animals Antineoplastic agents basidiomycetes beta-Glucosidase - metabolism Biological and medical sciences biotechnology blood serum Chick Embryo chicks Colonic Neoplasms - blood supply Colonic Neoplasms - drug therapy colorectal neoplasms CULTURE TECHNIQUES EXTRACTS Female FLAVONOIDS GANODERMA LUCIDUM General aspects GENISTEIN Genistein - blood Genistein - chemistry Genistein - pharmacology Genistein - therapeutic use GLUCOSIDASES Glycine max - chemistry glycosides Humans Hydrogen-Ion Concentration isoflavone aglycon isoflavone glycosides Isoflavones - analysis Isoflavones - metabolism Isoflavones - pharmacology Male Medical sciences Mice Mice, Inbred BALB C MORPHOGENESIS MYCELIUM Neovascularization, Pathologic - drug therapy Pharmacology. Drug treatments Plant Extracts - chemistry Plant Extracts - metabolism Plant Extracts - pharmacology Plant Extracts - therapeutic use polysaccharides Polysaccharides - chemistry Polysaccharides - pharmacology Polysaccharides - therapeutic use Reishi - chemistry Reishi - enzymology SOYBEANS Tumor Cells, Cultured VASCULAR TISSUES β-glucosidase |
| Title | Isoflavone aglycon produced by culture of soybean extracts with basidiomycetes and its anti-angiogenic activity |
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