Advancements in genetic research by the Hispanic Community Health Study/Study of Latinos: A 10-year retrospective review

The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is a multicenter, longitudinal cohort study designed to evaluate environmental, lifestyle, and genetic risk factors as they relate to cardiometabolic and other chronic diseases among Hispanic/Latino populations in the United States. Sin...

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Published inHGG advances Vol. 6; no. 1; p. 100376
Main Authors Rao, Hridya, Weiss, Margaret C., Moon, Jee Young, Perreira, Krista M., Daviglus, Martha L., Kaplan, Robert, North, Kari E., Argos, Maria, Fernández-Rhodes, Lindsay, Sofer, Tamar
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 09.01.2025
Elsevier
Subjects
Adult
Female
Genetic Research - ethics
Genetics
Hispanic or Latino - genetics
Humans
Longitudinal Studies
Male
Retrospective Studies
Review
United States
United States
Online AccessGet full text
ISSN2666-2477
2666-2477
DOI10.1016/j.xhgg.2024.100376

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Abstract The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is a multicenter, longitudinal cohort study designed to evaluate environmental, lifestyle, and genetic risk factors as they relate to cardiometabolic and other chronic diseases among Hispanic/Latino populations in the United States. Since the study’s inception in 2008, as a result of the study’s robust genetic measures, HCHS/SOL has facilitated major contributions to the field of genetic research. This 10-year retrospective review highlights the major findings for genotype-phenotype relationships and advancements in statistical methods owing to the HCHS/SOL. Furthermore, we discuss the ethical and societal challenges of genetic research, especially among Hispanic/Latino adults in the United States. Continued genetic research, ancillary study expansion, and consortia collaboration through HCHS/SOL will further drive knowledge and advancements in human genetics research. The authors review the contributions of genetic research in the Hispanic Community Health Study/Study of Latinos. The review summarizes methodological research advances, studies of genetic architecture of complex traits at both the single-variant and polygenic levels, integrative omics studies, ethical and social implications, and future directions.
AbstractList The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is a multicenter, longitudinal cohort study designed to evaluate environmental, lifestyle, and genetic risk factors as they relate to cardiometabolic and other chronic diseases among Hispanic/Latino populations in the United States. Since the study’s inception in 2008, as a result of the study’s robust genetic measures, HCHS/SOL has facilitated major contributions to the field of genetic research. This 10-year retrospective review highlights the major findings for genotype-phenotype relationships and advancements in statistical methods owing to the HCHS/SOL. Furthermore, we discuss the ethical and societal challenges of genetic research, especially among Hispanic/Latino adults in the United States. Continued genetic research, ancillary study expansion, and consortia collaboration through HCHS/SOL will further drive knowledge and advancements in human genetics research. The authors review the contributions of genetic research in the Hispanic Community Health Study/Study of Latinos. The review summarizes methodological research advances, studies of genetic architecture of complex traits at both the single-variant and polygenic levels, integrative omics studies, ethical and social implications, and future directions.
The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is a multicenter, longitudinal cohort study designed to evaluate environmental, lifestyle, and genetic risk factors as they relate to cardiometabolic and other chronic diseases among Hispanic/Latino populations in the United States. Since the study’s inception in 2008, as a result of the study’s robust genetic measures, HCHS/SOL has facilitated major contributions to the field of genetic research. This 10-year retrospective review highlights the major findings for genotype-phenotype relationships and advancements in statistical methods owing to the HCHS/SOL. Furthermore, we discuss the ethical and societal challenges of genetic research, especially among Hispanic/Latino adults in the United States. Continued genetic research, ancillary study expansion, and consortia collaboration through HCHS/SOL will further drive knowledge and advancements in human genetics research.
The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is a multicenter, longitudinal cohort study designed to evaluate environmental, lifestyle, and genetic risk factors as they relate to cardiometabolic and other chronic diseases among Hispanic/Latino populations in the United States. Since the study's inception in 2008, as a result of the study's robust genetic measures, HCHS/SOL has facilitated major contributions to the field of genetic research. This 10-year retrospective review highlights the major findings for genotype-phenotype relationships and advancements in statistical methods owing to the HCHS/SOL. Furthermore, we discuss the ethical and societal challenges of genetic research, especially among Hispanic/Latino adults in the United States. Continued genetic research, ancillary study expansion, and consortia collaboration through HCHS/SOL will further drive knowledge and advancements in human genetics research.The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is a multicenter, longitudinal cohort study designed to evaluate environmental, lifestyle, and genetic risk factors as they relate to cardiometabolic and other chronic diseases among Hispanic/Latino populations in the United States. Since the study's inception in 2008, as a result of the study's robust genetic measures, HCHS/SOL has facilitated major contributions to the field of genetic research. This 10-year retrospective review highlights the major findings for genotype-phenotype relationships and advancements in statistical methods owing to the HCHS/SOL. Furthermore, we discuss the ethical and societal challenges of genetic research, especially among Hispanic/Latino adults in the United States. Continued genetic research, ancillary study expansion, and consortia collaboration through HCHS/SOL will further drive knowledge and advancements in human genetics research.
ArticleNumber 100376
Author Rao, Hridya
Weiss, Margaret C.
Argos, Maria
Sofer, Tamar
Kaplan, Robert
Perreira, Krista M.
Fernández-Rhodes, Lindsay
Moon, Jee Young
North, Kari E.
Daviglus, Martha L.
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Snippet The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is a multicenter, longitudinal cohort study designed to evaluate environmental, lifestyle, and...
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SubjectTerms Adult
Female
Genetic Research - ethics
Genetics
Hispanic or Latino - genetics
Humans
Longitudinal Studies
Male
Retrospective Studies
Review
United States
Title Advancements in genetic research by the Hispanic Community Health Study/Study of Latinos: A 10-year retrospective review
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