Advancements in genetic research by the Hispanic Community Health Study/Study of Latinos: A 10-year retrospective review

• Published in: HGG advances Vol. 6; no. 1; p. 100376
• Main Authors: Rao, Hridya, Weiss, Margaret C., Moon, Jee Young, Perreira, Krista M., Daviglus, Martha L., Kaplan, Robert, North, Kari E., Argos, Maria, Fernández-Rhodes, Lindsay, Sofer, Tamar
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 09.01.2025; Elsevier
• Subjects: Adult; Female; Genetic Research - ethics; Genetics; Hispanic or Latino - genetics; Humans; Longitudinal Studies; Male; Retrospective Studies; Review; United States; United States
• ISSN: 2666-2477; 2666-2477
• DOI: 10.1016/j.xhgg.2024.100376

The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is a multicenter, longitudinal cohort study designed to evaluate environmental, lifestyle, and genetic risk factors as they relate to cardiometabolic and other chronic diseases among Hispanic/Latino populations in the United States. Since the study’s inception in 2008, as a result of the study’s robust genetic measures, HCHS/SOL has facilitated major contributions to the field of genetic research. This 10-year retrospective review highlights the major findings for genotype-phenotype relationships and advancements in statistical methods owing to the HCHS/SOL. Furthermore, we discuss the ethical and societal challenges of genetic research, especially among Hispanic/Latino adults in the United States. Continued genetic research, ancillary study expansion, and consortia collaboration through HCHS/SOL will further drive knowledge and advancements in human genetics research. The authors review the contributions of genetic research in the Hispanic Community Health Study/Study of Latinos. The review summarizes methodological research advances, studies of genetic architecture of complex traits at both the single-variant and polygenic levels, integrative omics studies, ethical and social implications, and future directions.