Virus-derived gene transfer agents benefit host cells by providing templates for DNA repair

The potential benefits of producing gene transfer agents (GTAs) have long been speculated. A new study in PLOS Biology shows that DNA transfer by these phage-like elements allows cells with DNA damage to perform DNA repair and survive.

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Bibliographic Details
Published inPLoS biology Vol. 20; no. 11; p. e3001874
Main Author Lang, Andrew S.
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 08.11.2022
Subjects
Analysis
Bacteria
Bacteriophages - genetics
Biology and life sciences
Caulobacter crescentus
Deoxyribonucleic acid
DNA
DNA damage
DNA Repair
Gene expression
Gene transfer
Gene Transfer, Horizontal
Genetic engineering
Genetic transformation
Genomes
Laboratories
Organisms
Phages
Primer
Prophages - genetics
Proteins
Viruses
Canada
Online AccessGet full text
ISSN1545-7885
1544-9173
1545-7885
DOI10.1371/journal.pbio.3001874

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Summary:The potential benefits of producing gene transfer agents (GTAs) have long been speculated. A new study in PLOS Biology shows that DNA transfer by these phage-like elements allows cells with DNA damage to perform DNA repair and survive.
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The authors have declared that no competing interests exist.
ISSN:1545-7885
1544-9173
1545-7885
DOI:10.1371/journal.pbio.3001874