淋巴结清扫数目对无淋巴结转移SiewertⅡ型食管胃交界部腺癌患者预后的影响
目的:探讨淋巴结清扫数目对无淋巴结转移( pN0期) SiewertⅡ型食管胃交界部腺癌患者预后的影响。方法回顾性分析1998年1月至2008年12月接受左进胸入路部分食管胃切除+传统二野(中下纵隔+腹腔)淋巴结清扫术、术后病理证实为无淋巴结转移的248例SiewertⅡ型食管胃交界部腺癌患者的临床病理资料。结果全组患者的中位生存时间为64个月,1、3、5年生存率分别为80.4%、60.8%和51.0%。 Cox多因素分析结果显示,淋巴结清扫数目和肿瘤浸润深度为影响患者预后的独立因素(均P<0.05)。相同T分期患者的生存率随淋巴结清扫数目的增加而提高,差异均有统计学意义(均P<0.05)。...
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Published in | 中华肿瘤杂志 Vol. 38; no. 4; pp. 300 - 304 |
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Main Author | |
Format | Journal Article |
Language | Chinese |
Published |
安徽医科大学附属省立医院胸外科, 合肥,230000
2016
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Subjects | |
Online Access | Get full text |
ISSN | 0253-3766 |
DOI | 10.3760/cma.j.issn.0253-3766.2016.04.011 |
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Summary: | 目的:探讨淋巴结清扫数目对无淋巴结转移( pN0期) SiewertⅡ型食管胃交界部腺癌患者预后的影响。方法回顾性分析1998年1月至2008年12月接受左进胸入路部分食管胃切除+传统二野(中下纵隔+腹腔)淋巴结清扫术、术后病理证实为无淋巴结转移的248例SiewertⅡ型食管胃交界部腺癌患者的临床病理资料。结果全组患者的中位生存时间为64个月,1、3、5年生存率分别为80.4%、60.8%和51.0%。 Cox多因素分析结果显示,淋巴结清扫数目和肿瘤浸润深度为影响患者预后的独立因素(均P<0.05)。相同T分期患者的生存率随淋巴结清扫数目的增加而提高,差异均有统计学意义(均P<0.05)。 T1期患者中,淋巴结清扫数目≥10枚患者的中位生存时间和5年生存率均高于清扫数目<10枚的患者,差异有统计学意义( P<0.001);T2期和T3期患者中,淋巴结清扫数目≥15枚患者的中位生存时间和5年生存率均高于清扫数目<15枚的患者,差异均有统计学意义(均P<0.05)。结论淋巴结清扫数目和肿瘤浸润深度为影响pN0期SiewertⅡ型食管胃交界部腺癌患者预后的独立危险因素,清扫一定数量的淋巴结可以改善患者的远期生存率。 |
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Bibliography: | Wang Jinqian, Wei Dazhong, Xie Mingran, Xu Shibin, Ma Dongchun( Department of Thoracic Surgery, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei 230000, China) Objective To investigate the correlation between the number of dissected lymph nodes ( LNs) and the prognosis of patients with node-negative Siewert type ⅡAEG. Methods 248 patients with Siewert type Ⅱ AEG treated in our hospital between January 1998 and December 2008 were retrospectively assessed. All cases underwent left transthoracic subtotal esophagogastrectomy with conventional two-field lymphadenectomy, and were histopathologically proved to be without lymph node involvement. The prognostic impact of the number of dissected LNs was analyzed. Results The overall median survival time and the 1-, 3-, and 5-year overall survival rates were 64 months, 80. 4%, 60. 8% and 51. 0%, respectively. Cox regression showed that the number of dissected LNs and the depth of tumor invasion were independent prognostic factors. Patients with a h |
ISSN: | 0253-3766 |
DOI: | 10.3760/cma.j.issn.0253-3766.2016.04.011 |