Alterations of the salience network in obesity: A resting-state fMRI study

• Published in: Human brain mapping Vol. 34; no. 11; pp. 2786 - 2797
• Main Authors: García-García, Isabel, Jurado, María Ángeles, Garolera, Maite, Segura, Bàrbara, Sala-Llonch, Roser, Marqués-Iturria, Idoia, Pueyo, Roser, Sender-Palacios, María José, Vernet-Vernet, Maria, Narberhaus, Ana, Ariza, Mar, Junqué, Carme
• Format: Journal Article
• Language: English
• Published: New York, NY Blackwell Publishing Ltd 01.11.2013; Wiley-Liss; John Wiley & Sons, Inc; John Wiley and Sons Inc
• Subjects: Adolescent; Adult; Biological and medical sciences; Body Composition; Body Mass Index; Brain Mapping; Cognition - physiology; Data Interpretation, Statistical; Electrodiagnosis. Electric activity recording; Female; fMRI; Homeostasis - physiology; Humans; Hunger - physiology; Image Processing, Computer-Assisted; Investigative techniques, diagnostic techniques (general aspects); Limbic System - physiology; Magnetic Resonance Imaging; Male; Medical sciences; Memory - physiology; Mental Processes - physiology; Nerve Net - pathology; Nervous system; Neural Pathways - pathology; Neuropsychological Tests; obesity; Obesity - pathology; Obesity - psychology; Principal Component Analysis; Psychomotor Performance - physiology; putamen; Putamen - anatomy & histology; Putamen - physiology; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Regression Analysis; resting state; reward; salience; Verbal Learning - physiology; Young Adult; salience; Obesity; fMRI; Nervous system diseases; resting state; Radiodiagnosis; Nutrition disorder; Reward; Nuclear magnetic resonance imaging; Putamen; Nutritional status; reward; putamen; obesity
• ISSN: 1065-9471; 1097-0193; 1097-0193
• DOI: 10.1002/hbm.22104

Obesity is a major health problem in modern societies. It has been related to abnormal functional organization of brain networks believed to process homeostatic (internal) and/or salience (external) information. This study used resting‐state functional magnetic resonance imaging analysis to delineate possible functional changes in brain networks related to obesity. A group of 18 healthy adult participants with obesity were compared with a group of 16 lean participants while performing a resting‐state task, with the data being evaluated by independent component analysis. Participants also completed a neuropsychological assessment. Results showed that the functional connectivity strength of the putamen nucleus in the salience network was increased in the obese group. We speculate that this abnormal activation may contribute to overeating through an imbalance between autonomic processing and reward processing of food stimuli. A correlation was also observed in obesity between activation of the putamen nucleus in the salience network and mental slowness, which is consistent with the notion that basal ganglia circuits modulate rapid processing of information. Hum Brain Mapp 34:2786–2797, 2013. © 2012 Wiley Periodicals, Inc.