New Tubular Bioabsorbable Knitted Airway Stent: Feasibility Assessment for Delivery and Deployment in a Dog Model

• Published in: Ann Thorac Surg Vol. 78; no. 4; pp. 1438 - 1440
• Main Authors: Saito, Yukihito, Minami, Ken-ichiro, Kaneda, Hiroyuki, Okada, Takayuki, Maniwa, Tomohiro, Araki, Yoshiro, Imamura, Hiroji, Yamada, Hirokazu, Igaki, Keiji, Tamai, Hideo
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.10.2004; Elsevier BV; Elsevier Science
• Subjects: Absorbable Implants; Absorbable Implants - adverse effects; Animals; Biological and medical sciences; Bronchoscopy; Catheterization; Delivery. Postpartum. Lactation; Dogs; Equipment Design; Feasibility Studies; Granulation Tissue; Granulation Tissue - pathology; Gynecology. Andrology. Obstetrics; Lactic Acid; Medical sciences; Polyesters; Polymers; Stents; Stents - adverse effects; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the heart; Surgery of the respiratory system; Trachea; Trachea - injuries; Trachea - pathology; 15; Fissipedia; Endoprosthesis; Evaluation; Carnivora; Respiratory disease; Instrumentation therapy; Thorax; Stent; Vertebrata; Renal tubule; Mammalia; Animal; Surgery; Feasibility; Models; Delivery; Dog
• ISSN: 0003-4975; 1552-6259; 1552-6259
• DOI: 10.1016/S0003-4975(03)01408-5

The aim of this study was to determine whether it is possible to deliver and deploy a new device, a poly-L-lactic acid (PLLA) tubular knitted airway stent, under bronchoscopic guidance in a dog model. The delivery system consisted of a flexible balloon catheter (controlled radial expansion balloon dilator, M00558440, Boston Scientific Corporation, MA, USA) preloaded with a stent. A delivery catheter preloaded with a stent was advanced to a target point in the trachea under bronchoscopic guidance. Once the stent was positioned, the balloon was inflated for sixty seconds. The stent was in full contact with the tracheal wall upon deflation of the balloon. The stents were successfully delivered into the tracheal lumen and successfully deployed in all dogs. This is the first study to prove the feasibility of delivering and deploying the PLLA stents in a dog model, using a balloon expansion technique. Further investigation with large numbers of subjects and long-term follow-up will be necessary to assess the utility of the bioabsorbable knitted tubular stent before clinical applications begin.