从左右半结肠癌的生物学差异谈结直肠癌

结肠癌和直肠癌存在生物学行为的差异，根据在结直肠的近端和远端的生长部位，结直肠癌可以划分为不同的类型，这种生长部位的不同导致肿瘤生物学行为的差异，可能与胚胎的起源、不同部位肿瘤症状的不同导致确诊时间的差异有关。进一步的研究表明。原发肿瘤的K-ras、BRAF和微卫星不稳定性状态的不同影响了肿瘤对靶向药物的敏感性和患者预后。...

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Bibliographic Details
Published in中华肿瘤杂志 Vol. 38; no. 5; pp. 397 - 400
Main Author 徐建明
Format Journal Article
LanguageChinese
Published 军事医学科学院附属医院消化肿瘤科, 北京,100071 2016
Subjects
右侧
左侧
结肠肿瘤
药物疗法
预后
Left-sided
药物疗法
Prognosis
预后
左侧
Right-sided
结肠肿瘤
Subject words] Colonic neoplasms
Drug therapy
右侧
Online AccessGet full text
ISSN0253-3766
DOI10.3760/cma.j.issn.0253-3766.2016.05.016

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Summary:结肠癌和直肠癌存在生物学行为的差异，根据在结直肠的近端和远端的生长部位，结直肠癌可以划分为不同的类型，这种生长部位的不同导致肿瘤生物学行为的差异，可能与胚胎的起源、不同部位肿瘤症状的不同导致确诊时间的差异有关。进一步的研究表明。原发肿瘤的K-ras、BRAF和微卫星不稳定性状态的不同影响了肿瘤对靶向药物的敏感性和患者预后。
Bibliography:Xu Jianming（ Department of GI Oncology, Affiliated Hospital, Academy of Military Medical Sciences, Beijing 100071, China）
11-2152/R
Previous studies have demonstrated that there are biological differences between colon and rectal cancers. Recently, some authors have proposed that colorectal cancer could be classified into several categories according to the primary sites of the tumor, proximal or distal. It is speculated that the differences are due to different embryologic origin and time to initial diagnosis. Further evidence snpports that the molecular differences in the status of K-ras, BRAF, and microsatellite instability （ MSI ） based on primary sites in the bowel are the basis that impacts the response to therapeutic afents and patient prognosis.
Colonic neoplasms ; Left-sided ; Right-sided ; Drug therapy ; Prognosis
ISSN:0253-3766
DOI:10.3760/cma.j.issn.0253-3766.2016.05.016