Macromolecular tissue volume mapping of lateral geniculate nucleus subdivisions in living human brains

• Published in: NeuroImage (Orlando, Fla.) Vol. 265; p. 119777
• Main Authors: Oishi, Hiroki, Takemura, Hiromasa, Amano, Kaoru
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2023; Elsevier Limited; Elsevier
• Subjects: Brain research; Functional magnetic resonance imaging; Functional MRI; Geniculate Bodies - diagnostic imaging; Geniculate Bodies - physiology; Humans; Hypotheses; Lateral geniculate nucleus; Macromolecules; Magnetic resonance imaging; Magnocellular; Mapping; Medical imaging; Methods; Neuroimaging; Parvocellular; Photic Stimulation - methods; Psychophysics; Reproducibility of Results; Retina; Structural MRI; Thalamus; Vision; Visual cortex; Visual Cortex - diagnostic imaging; Visual Cortex - physiology; Visual Pathways - diagnostic imaging; Visual Pathways - physiology; Visual perception; Visual Perception - physiology; Visual stimuli; Visual system; Structural MRI; Visual system; Parvocellular; Functional MRI; Lateral geniculate nucleus; Magnocellular
• ISSN: 1053-8119; 1095-9572; 1095-9572
• DOI: 10.1016/j.neuroimage.2022.119777

•Structural MRI mapping of M and P subdivisions of LGN in individual living humans.•Locations of the identified subdivisions were consistent with ex vivo human LGN data.•fMRI showed stimulus selectivity difference between the identified M/P subdivisions.•Measurement of LGN MTV values and parcellation were stable across days. The lateral geniculate nucleus (LGN) is a key thalamic nucleus in the visual system, which has an important function in relaying retinal visual input to the visual cortex. The human LGN is composed mainly of magnocellular (M) and parvocellular (P) subdivisions, each of which has different stimulus selectivity in neural response properties. Previous studies have discussed the potential relationship between LGN subdivisions and visual disorders based on psychophysical data on specific types of visual stimuli. However, these relationships remain speculative because non-invasive measurements of these subdivisions are difficult due to the small size of the LGN. Here we propose a method to identify these subdivisions by combining two structural MR measures: high-resolution proton-density weighted images and macromolecular tissue volume (MTV) maps. We defined the M and P subdivisions based on MTV fraction data and tested the validity of the definition by (1) comparing the data with that from human histological studies, (2) comparing the data with functional magnetic resonance imaging measurements on stimulus selectivity, and (3) analyzing the test-retest reliability. The findings demonstrated that the spatial organization of the M and P subdivisions was consistent across subjects and in line with LGN subdivisions observed in human histological data. Moreover, the difference in stimulus selectivity between the subdivisions identified using MTV was consistent with previous physiology literature. The definition of the subdivisions based on MTV was shown to be robust over measurements taken on different days. These results suggest that MTV mapping is a promising approach for evaluating the tissue properties of LGN subdivisions in living humans. This method potentially will enable neuroscientific and clinical hypotheses about the human LGN subdivisions to be tested.