Management of knee osteoarthritis. Current status and future trends

• Published in: Biotechnology and bioengineering Vol. 114; no. 4; pp. 717 - 739
• Main Authors: Ondrésik, Marta, Azevedo Maia, Fatima R., da Silva Morais, Alain, Gertrudes, Ana C., Dias Bacelar, Ana H., Correia, Cristina, Gonçalves, Cristiana, Radhouani, Hajer, Amandi Sousa, Rui, Oliveira, Joaquim M., Reis, Rui L.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.04.2017
• Subjects: Arthritis; articular cartilage; Biocompatibility; Biocompatible Materials; Biomaterials; Biomedical engineering; Biomedical materials; Biotechnology; Cartilage; Cartilage diseases; Cartilage, Articular - cytology; Cartilage, Articular - physiology; Gene therapy; Genetic Therapy; Humans; Knee; Knees; Life span; Management; Osteoarthritis; Osteoarthritis, Knee - therapy; Regeneration; scaffolds; Surgical implants; Tissue Engineering; viscosupplementation; articular cartilage; tissue engineering; scaffolds; regeneration; osteoarthritis; viscosupplementation; gene therapy; biomaterials
• ISSN: 0006-3592; 1097-0290; 1097-0290
• DOI: 10.1002/bit.26182

ABSTRACT Osteoarthritis (OA) affects a large number of the population, and its incidence is showing a growing trend with the increasing life span. OA is the most prevalent joint condition worldwide, and currently, there is no functional cure for it. This review seeks to briefly overview the management of knee OA concerning standardized pharmaceutical and clinical approaches, as well as the new biotechnological horizons of OA treatment. The potential of biomaterials and state of the art of advanced therapeutic approaches, such as cell and gene therapy focused primarily on cartilage regeneration are the main subjects of this review. Biotechnol. Bioeng. 2017;114: 717–739. © 2016 Wiley Periodicals, Inc. The aim of the authors in this work was to summarize the current management of osteoarthritis, and discuss the potential of advanced therapies for future applications. After a brief introduction of the disease, the authors list and describe a set of biomaterials, as well as cells from various sources for combined cartilage regeneration. Gene therapy is also the subject of this review paper as a promising approach to resolve osteoarthritis.