Effect of difelikefalin, a selective kappa opioid receptor agonist, on respiratory depression: A randomized, double‐blind, placebo‐controlled trial

• Published in: Clinical and translational science Vol. 14; no. 5; pp. 1886 - 1893
• Main Authors: Viscusi, Eugene R., Torjman, Marc C., Munera, Catherine L., Stauffer, Joseph W., Setnik, Beatrice S., Bagal, Sukirti N.
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.09.2021; John Wiley and Sons Inc; Wiley
• Subjects: Adolescent; Adult; Adverse events; Agonists; Analgesics; Carbon dioxide; Carbon Dioxide - analysis; Central nervous system; Cross-Over Studies; Double-Blind Method; Double-blind studies; Female; Healthy Volunteers; Hemodialysis; Humans; Incidence; Kidney diseases; Male; Middle Aged; Narcotics; Nervous system; Opioid receptors (type kappa); Oxygen Saturation - drug effects; Paresthesia; Piperidines - administration & dosage; Piperidines - adverse effects; Placebos; Placebos - administration & dosage; Placebos - adverse effects; Pruritus; Pruritus - drug therapy; Pulse oximetry; Receptors, Opioid, kappa - agonists; Respiration; Respiratory Insufficiency - chemically induced; Respiratory Insufficiency - diagnosis; Respiratory Insufficiency - epidemiology; Respiratory Rate - drug effects; Young Adult
• ISSN: 1752-8054; 1752-8062; 1752-8062
• DOI: 10.1111/cts.13042

Difelikefalin, a selective kappa opioid receptor agonist designed to limit central nervous system (CNS) penetration, is under development for the treatment of pruritus. Its hydrophilic, small‐peptidic structure limits CNS entry, minimizing potential CNS‐mediated adverse events (AEs). This study assessed the effect of difelikefalin on key relevant measures of respiratory depression in healthy volunteers. This single‐center, randomized, double‐blind, placebo‐controlled, three‐way crossover study enrolled healthy, nonsmoking volunteers. Subjects were randomized to 1 of 3 treatment sequences of difelikefalin (1.0 or 5.0 mcg/kg i.v.) or placebo on sequential days with an intervening 24 (±2) h washout period. The primary end points included incidence of increased end‐tidal carbon dioxide (ETCO2) greater than or equal to 10 mm Hg versus baseline or a level greater than 50 mm Hg sustained greater than or equal to 30 seconds, and incidence of reduction in saturation of peripheral oxygen (SpO2) to less than 92% sustained greater than or equal to 30 seconds. Secondary end points included incidence of reduced respiratory rate and other safety assessments. Fifteen subjects were randomized and completed the study. No subject on placebo or difelikefalin met the increased ETCO2 or reduced SpO2 primary end point criteria for respiratory depression. All respiratory measures in each group remained near baseline values during 4‐h postdose observations. No subject met the reduced respiratory rate criterion or experienced clinically significant changes in ETCO2, SpO2, or respiratory rate. The most commonly reported treatment‐emergent AEs (TEAEs; ≥20% of subjects) were paresthesia, hypoesthesia, and somnolence in the difelikefalin arms. All TEAEs were mild and resolved without intervention. Difelikefalin 1.0 and 5.0 mcg/kg i.v. did not produce respiratory depression.