Triple-Reassortant Swine Influenza A (H1) in Humans in the United States, 2005–2009

Influenza is known to infect several different hosts, including humans, birds, and pigs. The influenza genome is structured in a way that allows for rapid recombination between strains across host species. In this report, 11 sporadic episodes of human infection from novel swine-associated influenza...

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Published inThe New England journal of medicine Vol. 360; no. 25; pp. 2616 - 2625
Main Authors Shinde, Vivek, Bridges, Carolyn B, Uyeki, Timothy M, Shu, Bo, Balish, Amanda, Xu, Xiyan, Lindstrom, Stephen, Gubareva, Larisa V, Deyde, Varough, Garten, Rebecca J, Harris, Meghan, Gerber, Susan, Vagasky, Susan, Smith, Forrest, Pascoe, Neal, Martin, Karen, Dufficy, Deborah, Ritger, Kathy, Conover, Craig, Quinlisk, Patricia, Klimov, Alexander, Bresee, Joseph S, Finelli, Lyn
Format Journal Article
LanguageEnglish
Published Waltham, MA Massachusetts Medical Society 18.06.2009
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ISSN0028-4793
1533-4406
1533-4406
DOI10.1056/NEJMoa0903812

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Summary:Influenza is known to infect several different hosts, including humans, birds, and pigs. The influenza genome is structured in a way that allows for rapid recombination between strains across host species. In this report, 11 sporadic episodes of human infection from novel swine-associated influenza viruses are documented and the associated clinical illness and virologic characteristics are described. In this report, 11 sporadic episodes of human infection from novel swine-associated influenza viruses are documented and the associated clinical illness and virologic characteristics are described. Pigs have been hypothesized to act as a mixing vessel for the reassortment of avian, swine, and human influenza viruses and might play an important role in the emergence of novel influenza viruses capable of causing a human pandemic. 1 – 3 Recent reports of widespread transmission of swine-origin influenza A (H1N1) viruses in humans in Mexico, the United States, and elsewhere highlight this ever-present threat to global public health. 4 , 5 Between the 1930s and the 1990s, the most commonly circulating swine influenza virus among pigs — classic swine influenza A (H1N1) — underwent little change. However, by the late 1990s, multiple . . .
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa0903812