Triple-Reassortant Swine Influenza A (H1) in Humans in the United States, 2005–2009
Influenza is known to infect several different hosts, including humans, birds, and pigs. The influenza genome is structured in a way that allows for rapid recombination between strains across host species. In this report, 11 sporadic episodes of human infection from novel swine-associated influenza...
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Published in | The New England journal of medicine Vol. 360; no. 25; pp. 2616 - 2625 |
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Main Authors | , , , , , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Waltham, MA
Massachusetts Medical Society
18.06.2009
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Subjects | |
Online Access | Get full text |
ISSN | 0028-4793 1533-4406 1533-4406 |
DOI | 10.1056/NEJMoa0903812 |
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Summary: | Influenza is known to infect several different hosts, including humans, birds, and pigs. The influenza genome is structured in a way that allows for rapid recombination between strains across host species. In this report, 11 sporadic episodes of human infection from novel swine-associated influenza viruses are documented and the associated clinical illness and virologic characteristics are described.
In this report, 11 sporadic episodes of human infection from novel swine-associated influenza viruses are documented and the associated clinical illness and virologic characteristics are described.
Pigs have been hypothesized to act as a mixing vessel for the reassortment of avian, swine, and human influenza viruses and might play an important role in the emergence of novel influenza viruses capable of causing a human pandemic.
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Recent reports of widespread transmission of swine-origin influenza A (H1N1) viruses in humans in Mexico, the United States, and elsewhere highlight this ever-present threat to global public health.
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Between the 1930s and the 1990s, the most commonly circulating swine influenza virus among pigs — classic swine influenza A (H1N1) — underwent little change. However, by the late 1990s, multiple . . . |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-General Information-1 content type line 14 ObjectType-Feature-3 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0028-4793 1533-4406 1533-4406 |
DOI: | 10.1056/NEJMoa0903812 |