A cohort study on the predictive capability of body composition for diabetes mellitus using machine learning

• Published in: Journal of diabetes and metabolic disorders Vol. 23; no. 1; pp. 773 - 781
• Main Authors: Nematollahi, Mohammad Ali, Askarinejad, Amir, Asadollahi, Arefeh, Bazrafshan, Mehdi, Sarejloo, Shirin, Moghadami, Mana, Sasannia, Sarvin, Farjam, Mojtaba, Homayounfar, Reza, Pezeshki, Babak, Amini, Mitra, Roshanzamir, Mohamad, Alizadehsani, Roohallah, Bazrafshan, Hanieh, Bazrafshan drissi, Hamed, Tan, Ru-San, Acharya, U. Rajendra, Islam, Mohammed Shariful Sheikh
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.06.2024; BioMed Central Ltd; Nature Publishing Group
• Subjects: Abdomen; Algorithms; Analysis; Artificial intelligence; Body composition; Body fat; Classification; Cohort analysis; Data mining; Datasets; Decision trees; Development and progression; Diabetes; Endocrinology; Machine learning; Medicine; Medicine & Public Health; Metabolic Diseases; Metabolism; Minority & ethnic groups; Obesity; Physiological aspects; Regression analysis; Research Article; Support vector machines; Type 2 diabetes; Diabetes; Cohort study; Body composition; Machine learning
• ISSN: 2251-6581; 2251-6581
• DOI: 10.1007/s40200-023-01350-x

Purpose We applied machine learning to study associations between regional body fat distribution and diabetes mellitus in a population of community adults in order to investigate the predictive capability. We retrospectively analyzed a subset of data from the published Fasa cohort study using individual standard classifiers as well as ensemble learning algorithms. Methods We measured segmental body composition using the Tanita Analyzer BC-418 MA (Tanita Corp, Japan). The following features were input to our machine learning model: fat-free mass, fat percentage, basal metabolic rate, total body water, right arm fat-free mass, right leg fat-free mass, trunk fat-free mass, trunk fat percentage, sex, age, right leg fat percentage, and right arm fat percentage. We performed classification into diabetes vs. no diabetes classes using linear support vector machine, decision tree, stochastic gradient descent, logistic regression, Gaussian naïve Bayes, k-nearest neighbors (k = 3 and k = 4), and multi-layer perceptron, as well as ensemble learning using random forest, gradient boosting, adaptive boosting, XGBoost, and ensemble voting classifiers with Top3 and Top4 algorithms. 4661 subjects (mean age 47.64 ± 9.37 years, range 35 to 70 years; 2155 male, 2506 female) were analyzed and stratified into 571 and 4090 subjects with and without a self-declared history of diabetes, respectively. Results Age, fat mass, and fat percentages in the legs, arms, and trunk were positively associated with diabetes; fat-free mass in the legs, arms, and trunk, were negatively associated. Using XGBoost, our model attained the best excellent accuracy, precision, recall, and F1-score of 89.96%, 90.20%, 89.65%, and 89.91%, respectively. Conclusions Our machine learning model showed that regional body fat compositions were predictive of diabetes status.