Ovarian Fibrosis： A Phenomenon of Concern

• Published in: Chinese medical journal Vol. 130; no. 3; pp. 365 - 371
• Main Authors: Zhou, Feng, Shi, Li-Bing, Zhang, Song-Ying
• Format: Journal Article
• Language: English
• Published: China Wolters Kluwer India Pvt. Ltd 05.02.2017; Lippincott Williams & Wilkins Ovid Technologies; Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China; Medknow Publications & Media Pvt Ltd; Wolters Kluwer
• Subjects: Animals; Cell adhesion & migration; Cell growth; Chemotherapy; Cytokine; Fibrosis; Ovarian Chocolate Cyst; Polycystic Ovarian Syndrome; Premature Ovarian Failure; Cytokines; Cytokines - metabolism; Diabetes; Female; Fibroblasts; Fibrosis - complications; Fibrosis - diagnosis; Fibrosis - etiology; Fibrosis - metabolism; Gynecology; Hospitals; Humans; Infertility, Female - etiology; Kinases; Obstetrics; Ovary - pathology; Quality of life; Radiation therapy; Researchers; Review; Vascular endothelial growth factor; 卵巢疾病; 基质金属蛋白酶组织抑制剂; 多囊卵巢综合征; 纤维化; 结缔组织生长因子; 血管内皮生长因子; 转化生长因子β1; 过氧化物酶体增殖物激活受体; Premature Ovarian Failure; Polycystic Ovarian Syndrome; Ovarian Chocolate Cyst; Cytokine; Fibrosis
• ISSN: 0366-6999; 2542-5641
• DOI: 10.4103/0366-6999.198931

Objective： Ovarian fibrosis is characterized by excessive proliferation of ovarian fibroblasts and deposition ofextracellular matrix （ECM） and it is one of the principal reasons for ovarian dysfunction. This review aimed to investigate the pathogenetic mechanism of ovarian fibrosis and to clarify the relationship between ovarian diseases and fibrosis. Data Sources： We searched PubMed for English language articles published up to November 2016. The search terms included ovarian fibrosis OR fibrosis, ovarian chocolate cyst OR ovarian endometrioma, polycystic ovarian syndrome （PCOS）, premature ovarian failure, ECM, matrix rnetalloproteinases （MMPs）, tissue inhibitors of matrix metalloproteinases （TIMPs）, transforming growth factor-beta 1 （TGF-[31）, connective tissue growth factor （CTGF）, peroxisome proliferator-activated receptor gamma （PPAR-T）, vascular endothelial growth factor （VEGF）, endothelin-1 （ET-1）, and combinations of these terms. Study Selection： Articles were obtained and reviewed to analyze the pathogenic mechanism of ovarian fibrosis and related ovarian diseases. Results： Many cytokines, such as MMPs, TIMPs, TGF-β1, CTGF, PPAR-γ, VEGK and ET- 1, are involved in ovarian fibrogenesis. Ovarian fibrogenesis is associated with various ovarian diseases, including ovarian chocolate cyst PCOS, and premature ovarian failure. One finding of particular interest is that fibrogenesis in peripheral tissues around an ovarian chocolate cyst commonly causes ovarian function diminution, and therefore, this medical problem should arouse widespread concern in clinicians worldwide. Conclusions： Patients with ovarian fibrosis are susceptible to infertility and tend to have decreased responses to assisted fertility treatment. Thus, protection of ovarian function should be a priority for women who wish to reproduce when making therapeutic decisions about ovarian fibrosis-related diseases.