Estimated GFR, Albuminuria, and Cognitive Performance: The Maastricht Study

• Published in: American journal of kidney diseases Vol. 69; no. 2; pp. 179 - 191
• Main Authors: Martens, Remy J.H., Kooman, Jeroen P., Stehouwer, Coen D.A., Dagnelie, Pieter C., van der Kallen, Carla J.H., Koster, Annemarie, Kroon, Abraham A., Leunissen, Karel M.L., Nijpels, Giel, van der Sande, Frank M., Schaper, Nicolaas C., Sep, Simone J.S., van Boxtel, Martin P.J., Schram, Miranda T., Henry, Ronald M.A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2017
• Subjects: Adult; Age Factors; Aged; albuminuria; Albuminuria - physiopathology; Cognition; cognitive function; cognitive performance; Cohort Studies; Cross-Sectional Studies; Estimated glomerular filtration rate (eGFR); executive function; Female; Glomerular Filtration Rate; Humans; information processing speed; kidney disease; kidney function; Male; memory function; middle age; Middle Aged; Nephrology; neuropsychological test battery; urinary albumin excretion (UAE); cognitive function; Estimated glomerular filtration rate (eGFR); kidney function; cognition; neuropsychological test battery; kidney disease; albuminuria; middle age; urinary albumin excretion (UAE); information processing speed; cognitive performance; memory function; executive function
• ISSN: 0272-6386; 1523-6838; 1523-6838
• DOI: 10.1053/j.ajkd.2016.04.017

Reduced estimated glomerular filtration rate (eGFR) and albuminuria have been associated with worse cognitive performance. However, few studies have examined whether these associations are confined to older individuals or may be extended to the middle-aged population. Cross-sectional analyses of a prospective population-based cohort study. 2,987 individuals aged 40 to 75 years from the general population (The Maastricht Study). eGFR and urinary albumin excretion (UAE). Memory function, information processing speed, and executive function. Analyses were adjusted for demographic variables (age, sex, and educational level), lifestyle factors (smoking behavior and alcohol consumption), depression, and cardiovascular disease risk factors (glucose metabolism status, waist circumference, total to high-density lipoprotein cholesterol ratio, triglyceride level, use of lipid-modifying medication, systolic blood pressure, use of antihypertensive medication, and prevalent cardiovascular disease). UAE was <15mg/24 h in 2,439 (81.7%) participants, 15 to <30 mg/24 h in 309 (10.3%), and ≥30mg/24 h in 239 (8.0%). In the entire study population, UAE≥30mg/24 h was associated with lower information processing speed as compared to UAE<15mg/24 h (β [SD difference] = −0.148; 95% CI, −0.263 to −0.033) after full adjustment, whereas continuous albuminuria was not. However, significant interaction terms (P for interaction < 0.05) suggested that albuminuria was most strongly and extensively associated with cognitive performance in older individuals. Mean (±SD) eGFR, estimated by the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) creatinine–cystatin C equation (eGFRcr-cys), was 88.4±14.6 mL/min/1.73m2. eGFRcr-cys was not associated with any of the domains of cognitive performance after full adjustment. However, significant interaction terms (P for interaction < 0.05) suggested that eGFRcr-cys was associated with cognitive performance in older individuals. Cross-sectional design, which limited causal inferences. In the entire study population, albuminuria was independently associated with lower information processing speed, whereas eGFRcr-cys was not associated with cognitive performance. However, both were more strongly and extensively associated with cognitive performance in older individuals.