Tubal ligation, hysterectomy and epithelial ovarian cancer in the New England Case–Control Study

• Published in: International journal of cancer Vol. 133; no. 10; pp. 2415 - 2421
• Main Authors: Rice, Megan S., Murphy, Megan A., Vitonis, Allison F., Cramer, Daniel W., Titus, Linda J., Tworoger, Shelley S., Terry, Kathryn L.
• Format: Journal Article
• Language: English
• Published: Hoboken, NJ Wiley-Blackwell 15.11.2013; Wiley Subscription Services, Inc
• Subjects: Adult; Biological and medical sciences; Cancer; Carcinoma, Ovarian Epithelial; Case-Control Studies; Confidence intervals; epithelial ovarian cancer; Female; Female genital diseases; Gynecology. Andrology. Obstetrics; Histology; Humans; Hysterectomy; Hysterectomy - methods; Hysterectomy - statistics & numerical data; Logistic Models; Medical research; Medical sciences; Middle Aged; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Neoplasms, Glandular and Epithelial - epidemiology; Neoplasms, Glandular and Epithelial - pathology; Neoplasms, Glandular and Epithelial - surgery; New England - epidemiology; Odds Ratio; Ovarian cancer; Ovarian Neoplasms - epidemiology; Ovarian Neoplasms - pathology; Ovarian Neoplasms - surgery; Risk; Risk Factors; Sterilization, Tubal - methods; Sterilization, Tubal - statistics & numerical data; tubal ligation; tubal sterilization; Tumors; Womens health; England; United Kingdom; Great Britain; Europe; New England; USA, New England; Ovary carcinoma; tubal sterilization; Ovary cancer; Malignant tumor; Case control study; Hysterectomy; tubal ligation; Female genital diseases; Ovarian diseases; Cancerology; Ligature; Treatment; Surgery; Sterilization; epithelial ovarian cancer; Cancer; hysterectomy
• ISSN: 0020-7136; 1097-0215; 1097-0215
• DOI: 10.1002/ijc.28249

Previous studies have observed that tubal ligation and hysterectomy are associated with a decreased risk of ovarian cancer; however, little is known about whether these associations vary by surgical characteristics, individual characteristics or tumor histology. We used logistic regression to examine tubal ligation, simple hysterectomy and hysterectomy with unilateral oophorectomy in relation to risk of epithelial ovarian cancer in the New England Case–Control Study. Our primary analysis included 2,265 cases and 2,333 controls. Overall, tubal ligation was associated with a lower risk of epithelial ovarian cancer [odds ratio (OR) = 0.82, 95% confidence interval (CI): 0.68–0.97], especially for endometrioid tumors (OR = 0.45, 95% CI: 0.29–0.69). The inverse association between tubal ligation and ovarian cancer risk was stronger for women who had undergone the procedure at the time of last delivery (OR = 0.60, 95% CI: 0.42–0.84) rather than at a later time (OR = 0.93, 95% CI: 0.75–1.15). Overall, simple hysterectomy was not associated with ovarian cancer risk (OR: 1.09, 95% CI: 0.83–1.42), although it was associated with a nonsignificant decreased risk of ovarian cancer among women who underwent the procedure at age 45 or older (RR: 0.64, 95% CI: 0.40–1.02) or within the last 10 years (OR = 0.65, 95% CI: 0.38–1.13). Overall, women who had a hysterectomy with a unilateral oophorectomy had significantly lower risk of ovarian cancer (OR = 0.65, 95% CI: 0.45–0.94). In summary, tubal ligation and hysterectomy with unilateral oophorectomy were inversely associated with ovarian cancer risk in a large population‐based case–control study. Additional research is necessary to understand the potential biologic mechanisms by which these procedures may reduce ovarian cancer risk. What's new? Tubal ligation and hysterectomy are generally known to lower ovarian cancer risk. However, little is known whether this risk reduction is influenced by the details of the surgical procedures or by the tumor histology. In this large case‐control study, the authors show that tubal ligation was associated with a 18% reduced risk in ovarian cancer with strongest effects in endometrioid tumors and among women who underwent the procedure after the last childbirth. No overall association with simple hysterectomy was observed but hysterectomy with unilateral oophorectomy lowered the risk by 35%, underscoring the benefit of the procedure in the prevention of ovarian cancer.