B期非小细胞肺癌术后预后因素分析
目的 探讨行根治性手术治疗的ⅠB期非小细胞肺癌（NSCLC）患者的预后因素。方法 回顾性分析2009年1月至2010年12月行肺癌根治术并经病理证实为ⅠB期的458例NSCLC患者的临床资料。男269例，女189例；年龄28～88岁，中位年龄61岁。单因素生存分析采用Kaplan-Meier法和Log rank检验，多因素生存分析采用Cox比例风险模型。结果 458例患者中，66例死亡，5年生存率为85.6%。单因素分析显示，年龄≥65岁、术前癌胚抗原（CEA）升高、术前第1秒用力呼气容积占预计值百分比（FEV1%pred）〈70%、有脉管癌栓和肿瘤低分化与患者的预后差均有关（均P〈0.05）...
Saved in:
| Published in | 中华肿瘤杂志 Vol. 39; no. 4; pp. 293 - 297 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
100021,国家癌症中心 中国医学科学院北京协和医学院肿瘤医院胸外科
2017
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0253-3766 |
| DOI | 10.3760/cma.j.issn.0253-3766.2017.04.011 |
Cover
| Abstract | 目的 探讨行根治性手术治疗的ⅠB期非小细胞肺癌（NSCLC）患者的预后因素。方法 回顾性分析2009年1月至2010年12月行肺癌根治术并经病理证实为ⅠB期的458例NSCLC患者的临床资料。男269例，女189例；年龄28～88岁，中位年龄61岁。单因素生存分析采用Kaplan-Meier法和Log rank检验，多因素生存分析采用Cox比例风险模型。结果 458例患者中，66例死亡，5年生存率为85.6%。单因素分析显示，年龄≥65岁、术前癌胚抗原（CEA）升高、术前第1秒用力呼气容积占预计值百分比（FEV1%pred）〈70%、有脉管癌栓和肿瘤低分化与患者的预后差均有关（均P〈0.05）。Cox多因素分析显示，术前CEA升高、术前FEV1%pred〈70%和肿瘤低分化与患者的预后差均有关（均P〈0.05）。结论 术前CEA升高、术前FEV1%pred〈70%和肿瘤低分化为影响ⅠB期NSCLC患者预后的独立危险因素；低分化ⅠB期NSCLC患者可从术后辅助化疗中获益。 |
|---|---|
| AbstractList | 目的 探讨行根治性手术治疗的ⅠB期非小细胞肺癌（NSCLC）患者的预后因素。方法 回顾性分析2009年1月至2010年12月行肺癌根治术并经病理证实为ⅠB期的458例NSCLC患者的临床资料。男269例，女189例；年龄28～88岁，中位年龄61岁。单因素生存分析采用Kaplan-Meier法和Log rank检验，多因素生存分析采用Cox比例风险模型。结果 458例患者中，66例死亡，5年生存率为85.6%。单因素分析显示，年龄≥65岁、术前癌胚抗原（CEA）升高、术前第1秒用力呼气容积占预计值百分比（FEV1%pred）〈70%、有脉管癌栓和肿瘤低分化与患者的预后差均有关（均P〈0.05）。Cox多因素分析显示，术前CEA升高、术前FEV1%pred〈70%和肿瘤低分化与患者的预后差均有关（均P〈0.05）。结论 术前CEA升高、术前FEV1%pred〈70%和肿瘤低分化为影响ⅠB期NSCLC患者预后的独立危险因素；低分化ⅠB期NSCLC患者可从术后辅助化疗中获益。 目的 探讨行根治性手术治疗的ⅠB期非小细胞肺癌(NSCLC)患者的预后因素.方法 回顾性分析2009年1月至2010年12月行肺癌根治术并经病理证实为ⅠB期的458例NSCLC患者的临床资料.男269例,女189例;年龄28~88岁,中位年龄61岁.单因素生存分析采用Kaplan-Meier法和Log rank检验,多因素生存分析采用Cox比例风险模型.结果 458例患者中,66例死亡,5年生存率为85.6%.单因素分析显示,年龄≥65岁、术前癌胚抗原(CEA)升高、术前第1秒用力呼气容积占预计值百分比(FEV1%pred)<70%、有脉管癌栓和肿瘤低分化与患者的预后差均有关(均P<0.05).Cox多因素分析显示,术前CEA升高、术前FEV1%pred<70%和肿瘤低分化与患者的预后差均有关(均P<0.05).结论 术前CEA升高、术前FEV1%pred<70%和肿瘤低分化为影响ⅠB期NSCLC患者预后的独立危险因素;低分化ⅠB期NSCLC患者可从术后辅助化疗中获益. |
| Abstract_FL | Objective To study the prognostic factors for patients with stage ⅠB non-small cell lung cancer (NSCLC) after radical operation (R0).Methods The clinical data of 458 patients who underwent radical resection for NSCLC and were pathologically diagnosed with stage ⅠB lung cancer from January 2009 to December 2010, were reviewed retrospectively.Those cases include 269 male patients and 189 female, aged between 28 and 88, with a median age of 61 years.The Kaplan-Meier method and Log rank test were used for univariate survival analysis and the Cox proportional hazards model for multivariate survival analysis.Results Among these 458 cases, 66 patients were dead and the 5-year survival rate was 85.6%.The results of the univariate analysis showed that the age ≥65 years, elevated preoperative CEA, preoperative FEV1%pred<70%, vascular carcinoma embolus, and low tumor differentiation were associated with poor prognosis of patients(P<0.05).The results of the multivariate analysis showed that elevated preoperative CEA, preoperative FEV1%pred<70% and low tumor differentiation were connected with poor prognosis of patients (P<0.05).Conclusions Elevated preoperative CEA, preoperative FEV1%pred<70% and low tumor differentiation are independent risk factors which influence prognosis and survival rate of patients with stage ⅠB NSCLC, among which those with poorly differentiated tumor could benefit from postoperative chemotherapy. |
| Author | 宋朋 臧若川 张默言 刘雷 高树庚 |
| AuthorAffiliation | 国家癌症中心中国医学科学院北京协和医学院肿瘤医院胸外科,100021 |
| AuthorAffiliation_xml | – name: 100021,国家癌症中心 中国医学科学院北京协和医学院肿瘤医院胸外科 |
| Author_FL | Song Peng Zhang Moyan Gao Shugeng Liu Lei Zang Ruochuan |
| Author_FL_xml | – sequence: 1 fullname: Song Peng – sequence: 2 fullname: Zang Ruochuan – sequence: 3 fullname: Zhang Moyan – sequence: 4 fullname: Liu Lei – sequence: 5 fullname: Gao Shugeng |
| Author_xml | – sequence: 1 fullname: 宋朋 臧若川 张默言 刘雷 高树庚 |
| BookMark | eNo9j81Kw0AUhWdRwVr7EoLgJuPcmUx-llr8g4Kb7sMkmWlT2okmiNilSnEh2q1Ya_EFdOFKnydJ-xaOVLyLe-Hwcc85G6imUy0R2gGCmeuQ3WgocB8nea4xoZxZRnQwJeBiYmMCUEP1f30dNfM8CQkH5ngMnDrC--X0dfkyKz4eq-_x4ma2uP6qnu7L6XsxeVi-3ZpdPM-rz3lxNy5nk020psQgl82_20Cdw4NO69hqnx6dtPbaVsRdanleKIltMkCoYp_6lPNIMEbjyAHgVFEmpFB27IPHFSNKhNKzFbGJZGZ8mzXQ9urtpdBK6G7QTy8ybQyDUW80-C1nYKCG21pxUS_V3fPEkGdZMhTZVeC44Lk-EMZ-ADwzY3M |
| ContentType | Journal Article |
| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| Copyright_xml | – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| DBID | 2RA 92L CQIGP W91 ~WA 2B. 4A8 92I 93N PSX TCJ |
| DOI | 10.3760/cma.j.issn.0253-3766.2017.04.011 |
| DatabaseName | 维普期刊资源整合服务平台 中文科技期刊数据库-CALIS站点 维普中文期刊数据库 中文科技期刊数据库-医药卫生 中文科技期刊数据库- 镜像站点 Wanfang Data Journals - Hong Kong WANFANG Data Centre Wanfang Data Journals 万方数据期刊 - 香港版 China Online Journals (COJ) China Online Journals (COJ) |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| DocumentTitleAlternate | Analysis of prognostic factors for patients with stageⅠb non-small cell lung cancer after operation |
| DocumentTitle_FL | Analysis of prognostic factors for patients with stageⅠb non-small cell lung cancer after operation |
| EndPage | 297 |
| ExternalDocumentID | zhzl201704012 671879103 |
| GroupedDBID | --- -05 123 2B. 2C~ 2RA 92F 92I 92L ABDBF ACGFS ALMA_UNASSIGNED_HOLDINGS CCEZO CIEJG CQIGP CW9 EOJEC OBODZ TCJ TGQ U1G U5O W91 ~WA 4A8 93N ABJNI ACUHS PSX |
| ID | FETCH-LOGICAL-c572-88be042011bfd929255ca332dc61152f23aeaf4d9185f30fabe84f040e3333943 |
| ISSN | 0253-3766 |
| IngestDate | Thu May 29 04:00:01 EDT 2025 Wed Feb 14 10:03:32 EST 2024 |
| IsPeerReviewed | false |
| IsScholarly | true |
| Issue | 4 |
| Keywords | Carcinoma Prognosis 预后 non-small-cell lung 肺外科手术 癌,非小细胞肺 Pulmonary surgical procedures |
| Language | Chinese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c572-88be042011bfd929255ca332dc61152f23aeaf4d9185f30fabe84f040e3333943 |
| Notes | Carcinoma, non-small-cell lung; Prognosis; Pulmonary surgical procedures Objective To study the prognostic factors for patients with stage ⅠB non-small cell lung cancer （NSCLC） after radical operation （R0）. Methods The clinical data of 458 patients who underwent radical resection for NSCLC and were pathologically diagnosed with stage ⅠB lung cancer from January 2009 to December 2010, were reviewed retrospectively. Those cases include 269 male patients and 189 female, aged between 28 and 88, with a median age of 61 years. The Kaplan-Meier method and Log rank test were used for univariate survival analysis and the Cox proportional hazards model for multivariate survival analysis. Results Among these 458 cases, 66 patients were dead and the 5-year survival rate was 85.6%.The results of the univariate analysis showed that the age ≥65 years, elevated preoperative CEA, preoperative FEV1%pred〈70%, vascular carcinoma embolus, and low tumor differentiation were associated with poor prognosis of patients（P〈0.05）. The re |
| PageCount | 5 |
| ParticipantIDs | wanfang_journals_zhzl201704012 chongqing_primary_671879103 |
| PublicationCentury | 2000 |
| PublicationDate | 2017 |
| PublicationDateYYYYMMDD | 2017-01-01 |
| PublicationDate_xml | – year: 2017 text: 2017 |
| PublicationDecade | 2010 |
| PublicationTitle | 中华肿瘤杂志 |
| PublicationTitleAlternate | Chinese Journal of Oncology |
| PublicationTitle_FL | Chinese Journal of Oncology |
| PublicationYear | 2017 |
| Publisher | 100021,国家癌症中心 中国医学科学院北京协和医学院肿瘤医院胸外科 |
| Publisher_xml | – name: 100021,国家癌症中心 中国医学科学院北京协和医学院肿瘤医院胸外科 |
| SSID | ssib051368316 ssib007279245 ssib000995398 ssj0042033 ssib017477325 ssib006576341 ssib001103529 ssib058574917 |
| Score | 2.1476488 |
| Snippet | 目的 探讨行根治性手术治疗的ⅠB期非小细胞肺癌（NSCLC）患者的预后因素。方法 回顾性分析2009年1月至2010年12月行肺癌根治术并经病理证实为ⅠB期的458例NSCLC患者的临床资... 目的 探讨行根治性手术治疗的ⅠB期非小细胞肺癌(NSCLC)患者的预后因素.方法 回顾性分析2009年1月至2010年12月行肺癌根治术并经病理证实为ⅠB期的458例NSCLC患者的临床资料.... |
| SourceID | wanfang chongqing |
| SourceType | Aggregation Database Publisher |
| StartPage | 293 |
| SubjectTerms | 癌，非小细胞肺 肺外科手术 预后 |
| Title | B期非小细胞肺癌术后预后因素分析 |
| URI | http://lib.cqvip.com/qk/93685X/201704/671879103.html https://d.wanfangdata.com.cn/periodical/zhzl201704012 |
| Volume | 39 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVEBS databaseName: EBSCOhost Academic Search Ultimate issn: 0253-3766 databaseCode: ABDBF dateStart: 20150223 customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn isFulltext: true dateEnd: 99991231 titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn omitProxy: true ssIdentifier: ssj0042033 providerName: EBSCOhost |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NbhMxELaiVkJcEAgQpVD1wEhIUcLu2ru2j7vJRhUSnILUW7S_jRCkBdJLjoAqDgh6RZRQ8QJw4AQvwIskad-CGe8mWRDiLwfLGnvGnozj-ezYY8Zu0KlJ5dlxI-cya9CTxo1IKrvhpJnUaWolKqd9yDt3va174va2u12rfaucWtofxs1k9Mt7Jf9jVaShXemW7D9YdiEUCZhH-2KKFsb0r2wcQOiBboHuQKhBt0GHELoQWKCQIiEIQHkQKlDcFGHGgcCnIq1BtUp2v0NcGrlCkuM7oESFgpkAfMsIFCbjglJGskdii4c45wgXQgGBAr9tqrWNhKJd0yWNRcIwtolIve2AXjhDIvghqLlmKqgbdgm-NBnsiWu4UFS7bnIt0ydN2qJ0rORjPatedpNImjQIZN1oV9TyiEnbRoAP2q_ufhTXPMvp0XE5TY9edS4vAiOVY1ZUJ-biHcbSxzuFXj-7DzoghDZPHkbN-6aR5qIROgQoTVDc0jf8GKTbk_Rqu01hZ1cd2hlaYat-0A46FSir3WqoRYRdiH2XUNLDhR-vQFNJkR2X__jiwlFKvpx7XZt7ihO0L1CHcCxuTlPMO3yG3Sw1uvUnfSisSH93sPMIwZK5uzbIo8FOBWZ1z7Nz5fpo0y8G-wVWG_UvsmYwPXp_-m48-fR69vXg5Nn45OmX2ZuX06OPk8NXpx-eYzp5ezz7fDx5cTAdH15i3U7YbW01yoc-Gokr0SGrOCMFbDvOU4TruMpNIs6dNPFwveLkDo-yKBepRmyZcyuP4kyJHL1PxvGjBb_MVga7g-wK2-SRsCVPnTRKhHCtKJYpFzpXXMV2EnNvja0vVO3tFfFcegvjrbGNUvle-St_0hv1Rw_ou8LmbOfqb9nX2VmqWWzQXWMrw8f72XWErMN4oxwN3wEUJWvS |
| linkProvider | EBSCOhost |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=B%E6%9C%9F%E9%9D%9E%E5%B0%8F%E7%BB%86%E8%83%9E%E8%82%BA%E7%99%8C%E6%9C%AF%E5%90%8E%E9%A2%84%E5%90%8E%E5%9B%A0%E7%B4%A0%E5%88%86%E6%9E%90&rft.jtitle=%E4%B8%AD%E5%8D%8E%E8%82%BF%E7%98%A4%E6%9D%82%E5%BF%97&rft.au=%E5%AE%8B%E6%9C%8B+%E8%87%A7%E8%8B%A5%E5%B7%9D+%E5%BC%A0%E9%BB%98%E8%A8%80+%E5%88%98%E9%9B%B7+%E9%AB%98%E6%A0%91%E5%BA%9A&rft.date=2017&rft.issn=0253-3766&rft.volume=39&rft.issue=4&rft.spage=293&rft.epage=297&rft_id=info:doi/10.3760%2Fcma.j.issn.0253-3766.2017.04.011&rft.externalDocID=671879103 |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fimage.cqvip.com%2Fvip1000%2Fqk%2F93685X%2F93685X.jpg http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Fzhzl%2Fzhzl.jpg |