B期非小细胞肺癌术后预后因素分析

目的 探讨行根治性手术治疗的ⅠB期非小细胞肺癌（NSCLC）患者的预后因素。方法 回顾性分析2009年1月至2010年12月行肺癌根治术并经病理证实为ⅠB期的458例NSCLC患者的临床资料。男269例，女189例；年龄28～88岁，中位年龄61岁。单因素生存分析采用Kaplan-Meier法和Log rank检验，多因素生存分析采用Cox比例风险模型。结果 458例患者中，66例死亡，5年生存率为85.6%。单因素分析显示，年龄≥65岁、术前癌胚抗原（CEA）升高、术前第1秒用力呼气容积占预计值百分比（FEV1%pred）〈70%、有脉管癌栓和肿瘤低分化与患者的预后差均有关（均P〈0.05）...

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Bibliographic Details
Published in中华肿瘤杂志 Vol. 39; no. 4; pp. 293 - 297
Main Author 宋朋 臧若川 张默言 刘雷 高树庚
Format Journal Article
LanguageChinese
Published 100021,国家癌症中心 中国医学科学院北京协和医学院肿瘤医院胸外科 2017
Subjects
癌，非小细胞肺
肺外科手术
预后
Carcinoma
Prognosis
预后
non-small-cell lung
肺外科手术
癌,非小细胞肺
Pulmonary surgical procedures
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ISSN0253-3766
DOI10.3760/cma.j.issn.0253-3766.2017.04.011

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Summary:目的 探讨行根治性手术治疗的ⅠB期非小细胞肺癌（NSCLC）患者的预后因素。方法 回顾性分析2009年1月至2010年12月行肺癌根治术并经病理证实为ⅠB期的458例NSCLC患者的临床资料。男269例，女189例；年龄28～88岁，中位年龄61岁。单因素生存分析采用Kaplan-Meier法和Log rank检验，多因素生存分析采用Cox比例风险模型。结果 458例患者中，66例死亡，5年生存率为85.6%。单因素分析显示，年龄≥65岁、术前癌胚抗原（CEA）升高、术前第1秒用力呼气容积占预计值百分比（FEV1%pred）〈70%、有脉管癌栓和肿瘤低分化与患者的预后差均有关（均P〈0.05）。Cox多因素分析显示，术前CEA升高、术前FEV1%pred〈70%和肿瘤低分化与患者的预后差均有关（均P〈0.05）。结论 术前CEA升高、术前FEV1%pred〈70%和肿瘤低分化为影响ⅠB期NSCLC患者预后的独立危险因素；低分化ⅠB期NSCLC患者可从术后辅助化疗中获益。
Bibliography:Carcinoma, non-small-cell lung; Prognosis; Pulmonary surgical procedures
Objective To study the prognostic factors for patients with stage ⅠB non-small cell lung cancer （NSCLC） after radical operation （R0）. Methods The clinical data of 458 patients who underwent radical resection for NSCLC and were pathologically diagnosed with stage ⅠB lung cancer from January 2009 to December 2010, were reviewed retrospectively. Those cases include 269 male patients and 189 female, aged between 28 and 88, with a median age of 61 years. The Kaplan-Meier method and Log rank test were used for univariate survival analysis and the Cox proportional hazards model for multivariate survival analysis. Results Among these 458 cases, 66 patients were dead and the 5-year survival rate was 85.6%.The results of the univariate analysis showed that the age ≥65 years, elevated preoperative CEA, preoperative FEV1%pred〈70%, vascular carcinoma embolus, and low tumor differentiation were associated with poor prognosis of patients（P〈0.05）. The re
ISSN:0253-3766
DOI:10.3760/cma.j.issn.0253-3766.2017.04.011