Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL)

• Published in: Nature genetics Vol. 42; no. 4; pp. 292 - 294
• Main Authors: Franke, Andre, Balschun, Tobias, Sina, Christian, Ellinghaus, David, Häsler, Robert, Mayr, Gabriele, Albrecht, Mario, Wittig, Michael, Buchert, Eva, Nikolaus, Susanna, Gieger, Christian, Wichmann, H Erich, Sventoraityte, Jurgita, Kupcinskas, Limas, Onnie, Clive M, Gazouli, Maria, Anagnou, Nicholas P, Strachan, David, McArdle, Wendy L, Mathew, Christopher G, Rutgeerts, Paul, Vermeire, Séverine, Vatn, Morten H, Krawczak, Michael, Rosenstiel, Philip, Karlsen, Tom H, Schreiber, Stefan
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.04.2010; Nature Publishing Group
• Subjects: 631/208/205/2138; 631/208/212/748; 631/208/727/2000; 692/699/1503/1581/257/1389; Agriculture; Animal Genetics and Genomics; Biomedical and Life Sciences; Biomedicine; brief-communication; Cancer Research; Chromosomes; Chromosomes, Human, Pair 22; Chromosomes, Human, Pair 7; Colitis, Ulcerative - genetics; Gene Function; Gene loci; Genetic aspects; Genetic Predisposition to Disease; Genetics; Genome-Wide Association Study; Health sciences; Human Genetics; Humans; Identification and classification; Inflammatory bowel disease; Polymorphism, Single Nucleotide; Quantitative trait loci; Receptors, Interleukin-17 - genetics; Risk Factors; Ulcerative colitis; Norway; United Kingdom; Germany
• ISSN: 1061-4036; 1546-1718; 1546-1718
• DOI: 10.1038/ng.553

Andre Franke and colleagues report results of a genome-wide association and replication study of ulcerative colitis. They identify two new regions of association at 7q22 and at 22q13 in IL17REL . We performed a genome-wide association analysis of 1,897,764 SNPs in 1,043 German ulcerative colitis (UC) cases and 1,703 controls. We discovered new associations at chromosome 7q22 (rs7809799) and at chromosome 22q13 in IL17REL (rs5771069) and confirmed these associations in six replication panels (2,539 UC cases and 5,428 controls) from different regions of Europe (overall study sample P rs7809799 = 8.81 × 10 −11 and P rs5771069 = 4.21 × 10 −8 , respectively).