Anti-HMGCR Specificity of HALIP: A Confirmatory Study

A distinctive new indirect immunofluorescence pattern in liver tissue has been associated with anti-HMGCR autoantibodies. It is known as HALIP (HMGCR Associated Liver Immunofluorescence Pattern). In this study, we furthered the original studies to demonstrate the association of anti-HMGCR antibodies...

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Published inJournal of Immunology Research Vol. 2020; no. 2020; pp. 1 - 4
Main Authors Selva-O'Callaghan, Albert, Martinez-Martinez, Laura, Mariscal, Anaís, Alvarado-Cardenas, Marcelo, Martinez, Maria Angeles, Baucells, Andrés, Juárez-Rubio, Cándido
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 2020
Hindawi
John Wiley & Sons, Inc
Wiley
Subjects
Antibodies
Antigens
Autoantibodies
Autoimmunity
Immunofluorescence
Immunology
Kidneys
Laboratories
Liver
Patients
Proteins
Statins
Online AccessGet full text
ISSN2314-8861
2314-7156
2314-7156
DOI10.1155/2020/6292631

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Summary:A distinctive new indirect immunofluorescence pattern in liver tissue has been associated with anti-HMGCR autoantibodies. It is known as HALIP (HMGCR Associated Liver Immunofluorescence Pattern). In this study, we furthered the original studies to demonstrate the association of anti-HMGCR antibodies with the HALIP. Human anti-HMGCR antibodies from patients’ sera were purified and incubated with rat triple tissue (kidney/stomach/liver). A characteristic HALIP was observed. Additionally, a colocalization assay of human anti-HMGCR antibodies with rabbit polyclonal anti-HMGCR antibodies showed colocalization of both immunofluorescence patterns. This study confirms that the HALIP is due to human anti-HMGCR antibodies.
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Academic Editor: Giuseppe A. Sautto
ISSN:2314-8861
2314-7156
2314-7156
DOI:10.1155/2020/6292631